Pre_GI: BLASTP Hits

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Query: NC_008593:196257:208992 Clostridium novyi NT, complete genome

Start: 208992, End: 210059, Length: 1068

Host Lineage: Clostridium novyi; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain (NT) was created so that it lacks the lethal toxin. Injection of spores of this organism into mice harboring tumors resulted in an increased immune response and destruction of the tumor tissue in a method known as COBALT (combination bacteriolytic therapy) when the spores along with chemotherapeutic agents or radiation are co-administered. The anaerobic bacteria preferentially target hypoxic cancer tissue and stimulate immune responses to that tissue. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. Some species are capable of producing organic solvents (acetone, ethanol, etc,), molecular hydrogen and other useful compounds. Clostridium novyi is an anaerobic bacterium found in soil, aquatic sediments, and intestinal tract of both animals and humans. Some types produce lethal toxins.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_015425:198315:2136642136642147281065Clostridium botulinum BKT015925 chromosome, complete genomehypothetical protein5e-174610
NC_011837:165913:1873961873961884781083Clostridium kluyveri NBRC 12016, complete genomeDNA integrity scanning protein DisA6e-150530
NC_021182:4602683:4602683460268346037561074Clostridium pasteurianum BC1, complete genomeputative nucleic-acid-binding protein (contains the HHH domain)9e-150530
NC_009697:3711692:3711692371169237127531062Clostridium botulinum A str. ATCC 19397 chromosome, completeDNA integrity scanning protein DisA1e-145515
NC_009495:3735703:3735703373570337367641062Clostridium botulinum A str. ATCC 3502 chromosome, complete genomeDNA integrity scanning protein DisA1e-145515
NC_015687:3326461:3326461332646133275341074Clostridium acetobutylicum DSM 1731 chromosome, complete genomeDNA integrity scanning protein DisA4e-139494
NC_003030:3324834:3324834332483433259071074Clostridium acetobutylicum ATCC 824, complete genomePredicted nucleic-acid-binding protein protein, containing HHH domain, YACK B.subtilis ortholog4e-139494
NC_020291:166500:1666811666811677631083Clostridium saccharoperbutylacetonicum N1-4(HMT), complete genomeDNA integrity scanning protein DisA5e-138491
NC_008262:2598920:2646594264659426476581065Clostridium perfringens SM101, complete genomeDomain of unknown function DUF147 family3e-136484
NC_010723:223935:2239352239352249991065Clostridium botulinum E3 str. Alaska E43, complete genomeDNA integrity scanning protein DisA1e-135483
NC_009617:163466:1650811650811661451065Clostridium beijerinckii NCIMB 8052 chromosome, complete genomeDNA integrity scanning protein DisA3e-135481
NC_010674:222016:2220162220162230801065Clostridium botulinum B str. Eklund 17B, complete genomeDNA integrity scanning protein DisA3e-135481
NC_014393:4482896:4527953452795345290261074Clostridium cellulovorans 743B chromosome, complete genomeDNA integrity scanning, DisA, linker region3e-129461
NC_015573:3167207:3166125316612531672101086Desulfotomaculum kuznetsovii DSM 6115 chromosome, complete genomeDNA integrity scanning protein disA4e-110398
NC_011899:86800:1080911080911091701080Halothermothrix orenii H 168, complete genomepredicted nucleic-acid-binding protein (contains the HHH domain)1e-107390
NC_014654:2138794:2138794213879421398731080Halanaerobium sp. 'sapolanicus' chromosome, complete genomeDNA integrity scanning, DisA, linker region6e-106384
NC_014378:131810:1503181503181514391122Acetohalobium arabaticum DSM 5501 chromosome, complete genomeDNA integrity scanning, DisA, linker region3e-103375
NC_009012:2100000:2105320210532021064021083Clostridium thermocellum ATCC 27405, complete genomeprotein of unknown function DUF1476e-103374
NC_007503:2098980:2101163210116321022211059Carboxydothermus hydrogenoformans Z-2901, complete genomeputative DNA-binding protein2e-101369
NC_013316:1:4670246702477721071Clostridium difficile R20291, complete genomeputative DNA-binding protein2e-98358
NC_002570:126500:1389041389041399771074Bacillus halodurans C-125, complete genomehypothetical protein5e-94344
NC_017208:64500:1025281025281036011074Bacillus thuringiensis serovar chinensis CT-43 chromosome, completeDNA integrity scanning protein DisA9e-91333
NC_011297:1296968:1303079130307913041341056Dictyoglomus thermophilum H-6-12, complete genomeDNA integrity scanning protein DisA4e-76285
NC_015514:3911655:3931993393199339330631071Cellulomonas fimi ATCC 484 chromosome, complete genomeDNA integrity scanning, DisA, linker region6e-76284
NC_008268:4669530:4693804469380446948891086Rhodococcus sp. RHA1, complete genomehypothetical protein4e-72271
NC_015499:352934:3540863540863551741089Thermodesulfobium narugense DSM 14796 chromosome, complete genomeDNA integrity scanning, DisA, linker region3e-71269