Pre_GI: BLASTP Hits

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Query: NC_005956:699206:706032 Bartonella henselae str. Houston-1, complete genome

Start: 706032, End: 706244, Length: 213

Host Lineage: Bartonella henselae; Bartonella; Bartonellaceae; Rhizobiales; Proteobacteria; Bacteria

General Information: Bartonella henselae str. Houston-1 (ATCC 49882) was isolated from human blood in Houston Texas. Causative agent of cat scratch fever. This group of alpha proteobacteria are unique among pathogens in that they cause angiogenic lesions. This organism was identified as the causative agent of cat scratch fever, a disease found commonly in children or in immunocompromised adults. The proliferation of the vascular endothelium (bacillary angiomatosis) is characterisitic of Bartonella infection and results in multiplication of the bacterium's host cells. Infected macrophages are stimulated to release vascular endothelial growth factor (VEGF) and interleukin 1 beta, both of which promote angiogenesis. Endothelial cells are also stimulated to grow and divide by direct contact with bacterial cells. In addition, programmed cell death (apoptosis) of endothelial cells is inhibited, combatting a common mechanism eukaryotic cells use to deal with bacterial infection. Other pathogenicity factors include pili and outer membrane adhesins for attachment to host cells.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_012846:825341:830298830298830510213Bartonella grahamii as4aup, complete genomepreprotein translocase subunit SecE1e-30131
NC_005955:841781:853808853808854020213Bartonella quintana str. Toulouse, complete genomePreprotein translocase secE subunit2e-30130
NC_020301:669000:677669677669677881213Bartonella vinsonii subsp. berkhoffii str. Winnie, complete genomepreprotein translocase subunit SecE5e-27119
NC_014932:985882:100079910007991001011213Bartonella clarridgeiae 73, complete genomepreprotein translocase, SecE subunit6e-23105
NC_020300:646500:656492656492656704213Bartonella australis Aust/NH1, complete genomepreprotein translocase subunit SecE3e-1477.4
NC_012587:1203103:122476812247681224968201Rhizobium sp. NGR234, complete genomeputative preprotein translocase, SecE subunit8e-1062.4
NC_015259:1803266:182354218235421823739198Polymorphum gilvum SL003B-26A1 chromosome, complete genomePreprotein translocase, SecE subunit7e-0855.8
NC_007626:3393940:339701933970193397216198Magnetospirillum magneticum AMB-1, complete genomePreprotein translocase subunit SecE3e-0753.5
NC_019907:920797:932334932334932540207Liberibacter crescens BT-1 chromosome, complete genomepreprotein translocase subunit SecE6e-0752.8
NC_007205:1059684:108522210852221085413192Candidatus Pelagibacter ubique HTCC1062, complete genomeProtein secE/sec61-gamma protein2e-0651.2