Pre_GI: BLASTP Hits

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Query: NC_005956:1648000:1663283 Bartonella henselae str. Houston-1, complete genome

Start: 1663283, End: 1663849, Length: 567

Host Lineage: Bartonella henselae; Bartonella; Bartonellaceae; Rhizobiales; Proteobacteria; Bacteria

General Information: Bartonella henselae str. Houston-1 (ATCC 49882) was isolated from human blood in Houston Texas. Causative agent of cat scratch fever. This group of alpha proteobacteria are unique among pathogens in that they cause angiogenic lesions. This organism was identified as the causative agent of cat scratch fever, a disease found commonly in children or in immunocompromised adults. The proliferation of the vascular endothelium (bacillary angiomatosis) is characterisitic of Bartonella infection and results in multiplication of the bacterium's host cells. Infected macrophages are stimulated to release vascular endothelial growth factor (VEGF) and interleukin 1 beta, both of which promote angiogenesis. Endothelial cells are also stimulated to grow and divide by direct contact with bacterial cells. In addition, programmed cell death (apoptosis) of endothelial cells is inhibited, combatting a common mechanism eukaryotic cells use to deal with bacterial infection. Other pathogenicity factors include pili and outer membrane adhesins for attachment to host cells.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_010161:2155500:217845021784502179028579Bartonella tribocorum CIP 105476, complete genomehypothetical protein2e-76284
NC_012846:2004711:201646020164602017029570Bartonella grahamii as4aup, complete genomehypothetical protein6e-75279
NC_014932:1314881:134501413450141345619606Bartonella clarridgeiae 73, complete genomehypothetical protein3e-62237
NC_008783:177161:192958192958193614657Bartonella bacilliformis KC583, complete genomehypothetical protein7e-60229
NC_008783:177161:192709192709192930222Bartonella bacilliformis KC583, complete genomehypothetical protein1e-1789.4
NC_019907:539749:546625546625547026402Liberibacter crescens BT-1 chromosome, complete genomehypothetical protein1e-1582.8