Pre_GI: BLASTP Hits

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Query: NC_005956:1648000:1657576 Bartonella henselae str. Houston-1, complete genome

Start: 1657576, End: 1657869, Length: 294

Host Lineage: Bartonella henselae; Bartonella; Bartonellaceae; Rhizobiales; Proteobacteria; Bacteria

General Information: Bartonella henselae str. Houston-1 (ATCC 49882) was isolated from human blood in Houston Texas. Causative agent of cat scratch fever. This group of alpha proteobacteria are unique among pathogens in that they cause angiogenic lesions. This organism was identified as the causative agent of cat scratch fever, a disease found commonly in children or in immunocompromised adults. The proliferation of the vascular endothelium (bacillary angiomatosis) is characterisitic of Bartonella infection and results in multiplication of the bacterium's host cells. Infected macrophages are stimulated to release vascular endothelial growth factor (VEGF) and interleukin 1 beta, both of which promote angiogenesis. Endothelial cells are also stimulated to grow and divide by direct contact with bacterial cells. In addition, programmed cell death (apoptosis) of endothelial cells is inhibited, combatting a common mechanism eukaryotic cells use to deal with bacterial infection. Other pathogenicity factors include pili and outer membrane adhesins for attachment to host cells.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_005956:1648000:1657853165785316589981146Bartonella henselae str. Houston-1, complete genomehypothetical protein4e-41166
NC_005956:1648000:165665016566501657579930Bartonella henselae str. Houston-1, complete genomehypothetical protein4e-34143
NC_014932:1314881:134203813420381342910873Bartonella clarridgeiae 73, complete genomehypothetical protein2e-1684.7
NC_008783:177161:1967971967971978131017Bartonella bacilliformis KC583, complete genomehypothetical protein2e-1477.8
NC_012846:2004711:2010633201063320117031071Bartonella grahamii as4aup, complete genomephage related protein7e-1475.9
NC_010161:2155500:2168831216883121698981068Bartonella tribocorum CIP 105476, complete genomehypothetical protein3e-1270.9