Pre_GI: BLASTP Hits

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Query: NC_005945:3725397:3744670 Bacillus anthracis str. Sterne, complete genome

Start: 3744670, End: 3745176, Length: 507

Host Lineage: Bacillus anthracis; Bacillus; Bacillaceae; Bacillales; Firmicutes; Bacteria

General Information: This strain carries the anthrax toxin plasmid pXO1 but not the capsule plasmid pXO2 and is therefore avirulent but toxigenic. It is the counterpart to the Pasteur strain that carries pXO2 but not pXO1. This strain is often used for vaccine development. Under starvation conditions this group of bacteria initiate a pathway that leads to endospore formation, a process that is thoroughly studied and is a model system for prokaryotic development and differentiation. Spores are highly resistant to heat, cold, dessication, radiation, and disinfectants, and enable the organism to persist in otherwise inhospitable environments. Under more inviting conditions the spores germinate to produce vegetative cells. This organism was the first to be shown to cause disease by Dr. Louis Pasteur (the organism, isolated from sick animals, was grown in the laboratory and then used to infect healthy animals and make them sick). This organism was also the first for which an attenuated strain was developed as a vaccine. Herbivorous animals become infected with the organism when they ingest spores from the soil whereas humans become infected when they come into contact with a contaminated animal. PA/LF and PA/EF complexes are internalized by host cells where the LF (metalloprotease) and EF (calmodulin-dependent adenylate cyclase) components act. At high levels LF induces cell death and release of the bacterium while EF increases host susceptibility to infection and promotes fluid accumulation in the cells.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_012659:3724729:374419837441983744704507Bacillus anthracis str. A0248, complete genomeputative DNA-binding protein8e-86315
NC_014335:3675456:369473836947383695244507Bacillus cereus biovar anthracis str. CI chromosome, completeDNA-binding protein8e-86315
NC_003997:3724702:374417137441713744677507Bacillus anthracis str. Ames, complete genomeDNA-binding protein, putative8e-86315
NC_007530:3724829:374429837442983744804507Bacillus anthracis str. 'Ames Ancestor', complete genomedna-binding protein, putative8e-86315
NC_006274:3805134:382441238244123824918507Bacillus cereus E33L, complete genomehypothetical protein8e-86315
NC_005957:3746891:376614137661413766647507Bacillus thuringiensis serovar konkukian str. 97-27, completehypothetical protein8e-86315
NC_016771:3665773:368496936849693685475507Bacillus cereus NC7401, complete genomeDNA-binding protein8e-84308
NC_011969:3657360:367655736765573677063507Bacillus cereus Q1 chromosome, complete genomeDNA-binding protein8e-84308
NC_004722:3886800:390612039061203906626507Bacillus cereus ATCC 14579, complete genomePrespore specific transcriptional activator rsfA2e-80297
NC_014171:3812247:382898838289883829494507Bacillus thuringiensis BMB171 chromosome, complete genomeprespore specific transcriptional activator RsfA2e-80297
NC_011772:3896635:391420139142013914707507Bacillus cereus G9842, complete genomeputative DNA-binding protein4e-79293
NC_017208:3928161:394577339457733946279507Bacillus thuringiensis serovar chinensis CT-43 chromosome, completeprespore specific transcriptional activator rsfA6e-79292
NC_011725:4373721:437693643769364377577642Bacillus cereus B4264 chromosome, complete genomeprespore-specific transcriptional regulator rsfA7e-2199.8
NC_004722:4333643:433364343336434334299657Bacillus cereus ATCC 14579, complete genomePrespore specific transcriptional activator rsfA7e-2199.8
NC_016023:1501553:152381115238111524521711Bacillus coagulans 36D1 chromosome, complete genometranscription factor, RsfA family2e-1581.6
NC_011775:185409:207748207748208284537Bacillus cereus G9842 plasmid pG9842_209, complete sequencetranscription factor, RsfA family3e-0961.2