Pre_GI: BLASTP Hits

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Query: NC_004741:3240909:3257894 Shigella flexneri 2a str. 2457T, complete genome

Start: 3257894, End: 3259465, Length: 1572

Host Lineage: Shigella flexneri; Shigella; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This is a highly virulent strain that has been widely used for genetic and clinical research. Causes enteric disease. This genus is named for the Japanese scientist (Shiga) who discovered them in the 1890s. They are closely related to the Escherichia group, and may be considered the same species. are human-specific pathogens that are transmitted via contaminated food and water and are the leading causes of endemic bacillary dysentery, and over 1 million deaths worldwide are attributed to them. The bacteria infect the epithelial lining of the colon, causing acute inflammation by entering the host cell cytoplasm and spreading intercellularly. are extremely virulent organisms that require very few cells in order to cause disease. Both the type III secretion system, which delivers effector molecules into the host cell, and some of the translocated effectors such as the invasion plasmid antigens (Ipas), are encoded on the plasmid. The bacterium produces a surface protein that localizes to one pole of the cell (IcsA) which binds to and promotes actin polymerization, resulting in movement of the bacterium through the cell cytoplasm, and eventually to neighboring cells, which results in inflammatory destruction of the mucosal lining. This organism, along with Shigella sonnei, is the major cause of shigellosis in industrialized countries and is responsible for endemic infections.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_017328:3289853:3306839330683933084101572Shigella flexneri 2002017 chromosome, complete genomeputative hydrolase01013
NC_004337:3249791:3266776326677632683471572Shigella flexneri 2a str. 301, complete genomeputative hydrolase01013
NC_012967:3191319:3208211320821132097821572Escherichia coli B str. REL606 chromosome, complete genome(D)-galactarate dehydrogenase01008
NC_012947:630757:6307576307576323281572Escherichia coli 'BL21-Gold(DE3)pLysS AG' chromosome, completegalactarate dehydratase01008
NC_012759:3143455:3160452316045231620231572Escherichia coli BW2952 chromosome, complete genome(D)-galactarate dehydrogenase01008
NC_000913:3256307:3273304327330432748751572Escherichia coli K12, complete genome(D)-galactarate dehydrogenase01008
NC_010473:3354052:3371049337104933726201572Escherichia coli str. K-12 substr. DH10B, complete genome(D)-galactarate dehydrogenase01008
AC_000091:3258377:3275137327513732767081572Escherichia coli W3110 DNA, complete genome(D)-galactarate dehydrogenase01008
NC_002695:3994970:4014517401451740160881572Escherichia coli O157:H7 str. Sakai, complete genomeputative hydrolase01007
NC_013941:3884725:3904159390415939057301572Escherichia coli O55:H7 str. CB9615 chromosome, complete genomegalactarate dehydratase01007
NC_009800:3307123:3323902332390233254731572Escherichia coli HS, complete genomegalactarate dehydratase01006
NC_010498:3488513:3505118350511835066891572Escherichia coli SMS-3-5, complete genomegalactarate dehydratase01006
NC_011750:3768692:3788126378812637896971572Escherichia coli IAI39 chromosome, complete genome(D)-galactarate dehydrogenase01006
NC_011751:3710786:3730222373022237317931572Escherichia coli UMN026 chromosome, complete genome(D)-galactarate dehydrogenase01004
NC_009801:3595001:3610159361015936117301572Escherichia coli E24377A, complete genomegalactarate dehydratase01004
CU928145:3608917:3630249363024936318201572Escherichia coli 55989 chromosome, complete genome(D)-galactarate dehydrogenase01004
CU928160:3344746:3361524336152433630951572Escherichia coli IAI1 chromosome, complete genome(D)-galactarate dehydrogenase01004
CP002185:3475991:3492986349298634945571572Escherichia coli W, complete genome(D)-galactarate dehydrogenase01004
NC_011748:3608917:3630249363024936318201572Escherichia coli 55989, complete genome(D)-galactarate dehydrogenase01004
NC_011415:3523364:3543086354308635446571572Escherichia coli SE11 chromosome, complete genomegalactarate dehydratase01004
NC_011741:3344746:3361524336152433630951572Escherichia coli IAI1 chromosome, complete genome(D)-galactarate dehydrogenase01004
NC_010468:613812:6138126138126153831572Escherichia coli ATCC 8739, complete genomegalactarate dehydratase01003
NC_015856:268034:2956062956062971801575Collimonas fungivorans Ter331 chromosome, complete genomeD-galactarate dehydratase1e-179629
NC_014166:1008266:1020256102025610217881533Arcobacter nitrofigilis DSM 7299 chromosome, complete genomegalactarate dehydratase3e-168592
CP002797:4603787:4612003461200346135201518Escherichia coli NA114, complete genomePutative altronate hydrolase5e-78292
NC_004431:1119700:114144611414461141946501Escherichia coli CFT073, complete genome5e-77288
NC_010557:316000:3233493233493249201572Burkholderia ambifaria MC40-6 chromosome 3, complete sequenceAltronate dehydratase1e-75284
NC_007912:1231436:1239717123971712412431527Saccharophagus degradans 2-40, complete genomeGlycogen debranching enzyme GlgX2e-75283
NC_010501:1868888:1893012189301218945381527Pseudomonas putida W619, complete genomeAltronate dehydratase9e-75281
NC_015556:1188500:1189983118998311915211539Pseudomonas fulva 12-X chromosome, complete genomeGalactarate dehydratase2e-68260
NC_008536:1778500:1782949178294917844841536Solibacter usitatus Ellin6076, complete genomeAltronate dehydratase7e-67254
NC_006510:1995916:2001923200192320030891167Geobacillus kaustophilus HTA426, complete genomehypothetical protein4e-58226
NC_014206:1618988:1635813163581316369791167Geobacillus sp. C56-T3 chromosome, complete genomealtronate dehydratase1e-57224
NC_014041:3197192:3198206319820631998221617Zunongwangia profunda SM-A87 chromosome, complete genomealtronate hydrolase9e-56218
NC_013716:5020204:5045582504558250470691488Citrobacter rodentium ICC168, complete genomealtronate hydrolase3e-51203
NC_015224:3892972:3930051393005139315411491Yersinia enterocolitica subsp. palearctica 105.5R(r) chromosome,altronate hydrolase4e-50199
NC_015510:5539153:5556960555696055586151656Haliscomenobacter hydrossis DSM 1100 chromosome, complete genomeAltronate dehydratase7e-50198
NC_014532:2989185:2998060299806029997001641Halomonas elongata DSM 2581, complete genomealtronate dehydratase1e-48194
NC_013061:1360081:1364522136452213661741653Pedobacter heparinus DSM 2366, complete genomeAltronate dehydratase2e-48193
NC_017281:433995:4499934499934511591167Campylobacter jejuni subsp. jejuni S3 chromosome, complete genomealtronate hydrolase1e-47191
NC_007503:1111457:1147120114712011482801161Carboxydothermus hydrogenoformans Z-2901, complete genomehydrolase, UxaA family1e-47191
NC_017279:437665:4545134545134556851173Campylobacter jejuni subsp. jejuni IA3902 chromosome, completeputative altronate hydrolase C-terminus2e-47190
NC_019978:1182056:1191155119115511923121158Halobacteroides halobius DSM 5150, complete genomealtronate dehydratase2e-47190
NC_007503:1111457:1118854111885411200111158Carboxydothermus hydrogenoformans Z-2901, complete genomehydrolase, UxaA family7e-44178
NC_010321:1703000:1712227171222717133871161Thermoanaerobacter pseudethanolicus ATCC 33223 chromosome, completealtronate dehydratase2e-42174
NC_014964:1695000:1704440170444017056001161Thermoanaerobacter brockii subsp. finnii Ako-1 chromosome, completeAltronate dehydratase2e-42174
NC_020418:1841138:1856838185683818584331596Morganella morganii subsp. morganii KT, complete genomeAltronate hydrolase1e-40168
NC_015151:1218390:1235574123557412367431170Vulcanisaeta moutnovskia 768-28 chromosome, complete genomealtronate dehydratase1e-40168
NC_002578:1434396:1439747143974714409101164Thermoplasma acidophilum DSM 1728, complete genomehypothetical protein6e-30132
NC_004431:1119700:114196511419651142171207Escherichia coli CFT073, complete genome2e-29130
NC_015520:2859820:2868031286803128691881158Mahella australiensis 50-1 BON chromosome, complete genomeGalactarate dehydratase2e-28127
NC_004431:1119700:114235411423541142593240Escherichia coli CFT073, complete genome2e-27124
NC_013223:2609697:2640716264071626418791164Desulfohalobium retbaense DSM 5692, complete genomeAltronate dehydratase5e-27122
NC_011894:3797500:3798020379802037993001281Methylobacterium nodulans ORS 2060, complete genomeD-galactarate dehydratase/Altronate hydrolase domain protein6e-26119
NC_017275:927814:9479549479549491201167Sulfolobus islandicus HVE10/4 chromosome, complete genomeD-galactarate dehydratase/Altronate hydrolase domain protein5e-25116
NC_013526:439813:4581814581814608472667Thermobaculum terrenum ATCC BAA-798 chromosome 2, complete genomeAltronate dehydratase4e-25116
NC_009440:1045882:1053649105364910548091161Metallosphaera sedula DSM 5348 chromosome, complete genomeD-galactarate dehydratase/Altronate hydrolase domain-containing protein7e-25115
NC_011978:1500663:1506254150625415074081155Thermotoga neapolitana DSM 4359, complete genomehypothetical protein8e-24112
NC_014541:643604:6652086652086663921185Ferrimonas balearica DSM 9799 chromosome, complete genomeAltronate dehydratase1e-22108
NC_014844:442380:4468564468564480551200Desulfovibrio aespoeensis Aspo-2 chromosome, complete genomeD-galactarate dehydratase/Altronate hydrolase domain-containing protein2e-20100
NC_011992:1912200:191471619147161915309594Acidovorax ebreus TPSY, complete genomeSMP-30/Gluconolaconase/LRE domain protein4e-1273.2
NC_004431:1119700:114206611420661142329264Escherichia coli CFT073, complete genome2e-1067.8