Pre_GI: BLASTP Hits

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Query: NC_004557:2677155:2696155 Clostridium tetani E88, complete genome

Start: 2696155, End: 2697003, Length: 849

Host Lineage: Clostridium tetani; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain is a virulent nonsporulating variant of strain Massachusetts used in vaccine production. Causes tetanus. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. Known opportunistic toxin-producing pathogens in animals and humans. Some species are capable of producing organic solvents (acetone, ethanol, etc,), molecular hydrogen and other useful compounds. This organism causes tetanus (lockjaw) in humans. At the tissue level, the bacterium then releases an exotoxin called tetanospasmin that causes certain nervous system irregularities by means of retrograde tramsmission through neurons to the brain. If nervous impulses cannot be checked by normal inhibitory mechanisms, it produces the generalized muscular spasms characteristic of tetanus.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_015690:4469775:452519745251974525982786Paenibacillus mucilaginosus KNP414 chromosome, complete genomehypothetical protein2e-76285
NC_016935:4233223:428103242810324281817786Paenibacillus mucilaginosus 3016 chromosome, complete genomehypothetical protein9e-76283
NC_015711:5250163:527274652727465273555810Myxococcus fulvus HW-1 chromosome, complete genomehypothetical protein7e-71267
NC_008095:3371673:337230233723023373156855Myxococcus xanthus DK 1622, complete genomehypothetical protein8e-69260
NC_014623:7720828:773970477397047740507804Stigmatella aurantiaca DW4/3-1 chromosome, complete genomehypothetical protein4e-67254
NC_006347:2190000:220788422078842208735852Bacteroides fragilis YCH46, complete genomeputative membrane-associated metal-dependent hydrolase1e-66253
NC_003228:2245181:226414022641402264991852Bacteroides fragilis NCTC 9343, complete genomehypothetical protein7e-66250
NC_016776:2237404:225657622565762257427852Bacteroides fragilis 638R, complete genomehypothetical protein8e-66250
NC_008820:91967:1442611442611471792919Prochlorococcus marinus str. MIT 9303, complete genomehypothetical protein7e-22104
NC_010814:1551624:1594064159406415955421479Geobacter lovleyi SZ, complete genomeMethyltransferase type 112e-1789.7