Pre_GI: BLASTP Hits

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Query: NC_004557:2677155:2685064 Clostridium tetani E88, complete genome

Start: 2685064, End: 2685648, Length: 585

Host Lineage: Clostridium tetani; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain is a virulent nonsporulating variant of strain Massachusetts used in vaccine production. Causes tetanus. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. Known opportunistic toxin-producing pathogens in animals and humans. Some species are capable of producing organic solvents (acetone, ethanol, etc,), molecular hydrogen and other useful compounds. This organism causes tetanus (lockjaw) in humans. At the tissue level, the bacterium then releases an exotoxin called tetanospasmin that causes certain nervous system irregularities by means of retrograde tramsmission through neurons to the brain. If nervous impulses cannot be checked by normal inhibitory mechanisms, it produces the generalized muscular spasms characteristic of tetanus.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_008593:1797000:179948017994801800064585Clostridium novyi NT, complete genomepyruvate synthase subunit porC3e-90330
NC_019978:39000:475694756948141573Halobacteroides halobius DSM 5150, complete genome2-oxoacid:acceptor oxidoreductase, gamma subunit, pyruvate/2-ketoisovalerate family1e-44179
NC_016751:1623756:163324516332451633820576Marinitoga piezophila KA3 chromosome, complete genome2-oxoacid:acceptor oxidoreductase subunit gamma, pyruvate/2-ketoisovalerate family1e-41169
NC_015499:491423:493698493698494273576Thermodesulfobium narugense DSM 14796 chromosome, complete genomepyruvate/ketoisovalerate oxidoreductase, gamma subunit1e-38159
NC_000961:597385:603707603707604264558Pyrococcus horikoshii OT3, complete genomeindolepyruvate ferredoxin oxidoreductase1e-35149
NC_003413:916398:930439930439930996558Pyrococcus furiosus DSM 3638, complete genomeindolepyruvate ferredoxin oxidoreductase9e-35146
NC_015474:1185478:118964911896491190206558Pyrococcus sp. NA2 chromosome, complete genomepyruvate/ketoisovalerate ferredoxin oxidoreductase subunit gamma7e-35146
NC_003901:1568000:160559516055951606143549Methanosarcina mazei Go1, complete genomepyruvate ferredoxin oxidoreductase subunit gamma2e-32138
NC_020389:1346358:137807313780731378621549Methanosarcina mazei Tuc01, complete genomePyruvate:ferredoxin oxidoreductase, gamma subunit2e-32138
NC_009464:2288500:230171923017192302258540Uncultured methanogenic archaeon RC-I, complete genomepyruvate:ferredoxin oxidoreductase, gamma subunit1e-29129
NC_010730:627465:630040630040630636597Sulfurihydrogenibium sp. YO3AOP1, complete genomepyruvate/ketoisovalerate oxidoreductase, gamma subunit1e-29129
NC_009635:1322860:134153613415361342063528Methanococcus aeolicus Nankai-3 chromosome, complete genomepyruvate ferredoxin oxidoreductase subunit gamma1e-29129
NC_013926:289511:296772296772297332561Aciduliprofundum boonei T469 chromosome, complete genomepyruvate/ketoisovalerate oxidoreductase, gamma subunit9e-29126
NC_016627:3158353:316437331643733164918546Clostridium clariflavum DSM 19732 chromosome, complete genome2-oxoacid:acceptor oxidoreductase, gamma subunit, pyruvate/2-ketoisovalerate family6e-28124
NC_009051:657000:688923688923689468546Methanoculleus marisnigri JR1, complete genomepyruvate/ketoisovalerate oxidoreductase, gamma subunit2e-27121
NC_014314:576465:592913592913593410498Dehalogenimonas lykanthroporepellens BL-DC-9 chromosome, completepyruvate/ketoisovalerate oxidoreductase subunit gamma3e-26118
NC_002754:2505750:251400625140062514560555Sulfolobus solfataricus P2, complete genomePyruvate synthase gamma chain (Pyruvic-ferredoxin oxidoreductase gamma chain) (porG-2)1e-24112
NC_000921:1147394:114833911483391148899561Helicobacter pylori J99, complete genomeindolepyruvate ferredoxin oxidoreductase3e-23107
NC_007644:362000:380851380851381399549Moorella thermoacetica ATCC 39073, complete genome2-oxoacid:acceptor oxidoreductase, gamma subunit, pyruvate/2-ketoisovalerate2e-21102
NC_008818:702452:719640719640720266627Hyperthermus butylicus DSM 5456, complete genomepyruvate oxidoreductase gamma subunit8e-21100
NC_015949:1180755:1195574119557411965931020Caldicellulosiruptor lactoaceticus 6A chromosome, complete genomepyruvate/ketoisovalerate oxidoreductase subunit gamma7e-2097.1
NC_014721:1777644:1792478179247817934971020Caldicellulosiruptor kristjanssonii 177R1B chromosome, completepyruvate/ketoisovalerate oxidoreductase, gamma subunit6e-2097.1
NC_012034:1783912:1798859179885917998781020Anaerocellum thermophilum DSM 6725, complete genomepyruvate/ketoisovalerate oxidoreductase, gamma subunit8e-2096.7
NC_014657:1518721:1534016153401615350351020Caldicellulosiruptor owensensis OL chromosome, complete genomepyruvate/ketoisovalerate oxidoreductase, gamma subunit1e-1996.3
NC_007759:2179000:218192921819292182456528Syntrophus aciditrophicus SB, complete genomepyruvate synthase gamma chain2e-1995.9
NC_014537:663216:676898676898677458561Vulcanisaeta distributa DSM 14429 chromosome, complete genomepyruvate/ketoisovalerate oxidoreductase subunit gamma2e-1995.5
NC_014392:969498:9944539944539954721020Caldicellulosiruptor obsidiansis OB47 chromosome, complete genomepyruvate/ketoisovalerate oxidoreductase, gamma subunit2e-1995.5
NC_014720:1161841:1166638116663811676571020Caldicellulosiruptor kronotskyensis 2002 chromosome, completepyruvate/ketoisovalerate oxidoreductase, gamma subunit3e-1994.7
NC_014652:1032711:1059267105926710602861020Caldicellulosiruptor hydrothermalis 108 chromosome, completepyruvate/ketoisovalerate oxidoreductase, gamma subunit3e-1994.7
NC_012622:327821:332818332818333366549Sulfolobus islandicus Y.G.57.14 chromosome, complete genomepyruvate/ketoisovalerate oxidoreductase subunit gamma3e-1994.7
NC_012623:2369671:237816823781682378716549Sulfolobus islandicus Y.N.15.51 chromosome, complete genomepyruvate/ketoisovalerate oxidoreductase subunit gamma3e-1994.7
NC_013769:316789:326299326299326847549Sulfolobus islandicus L.D.8.5 chromosome, complete genomepyruvate/ketoisovalerate oxidoreductase subunit gamma3e-1994.7
NC_009943:1637582:165609016560901656650561Candidatus Desulfococcus oleovorans Hxd3, complete genomepyruvate/ketoisovalerate oxidoreductase, gamma subunit4e-1994.4
NC_017276:320000:329935329935330483549Sulfolobus islandicus REY15A chromosome, complete genomepyruvate/ketoisovalerate oxidoreductase subunit gamma3e-1891.7
NC_009437:2367842:2382617238261723836361020Caldicellulosiruptor saccharolyticus DSM 8903, complete genomepyruvate/ketoisovalerate oxidoreductase, gamma subunit4e-1787.8
NC_015275:4577642:458535245853524585921570Clostridium lentocellum DSM 5427 chromosome, complete genomepyruvate/ketoisovalerate oxidoreductase, gamma subunit8e-1786.7
NC_015320:1342105:137641013764101376943534Archaeoglobus veneficus SNP6 chromosome, complete genomepyruvate/ketoisovalerate oxidoreductase subunit gamma5e-1477.4
NC_015587:28997:364923649237172681Hydrogenobaculum sp. SHO chromosome, complete genomepyruvate/ketoisovalerate oxidoreductase, gamma subunit3e-1271.6
NC_015557:30622:364563645637136681Hydrogenobaculum sp. 3684 chromosome, complete genomepyruvate/ketoisovalerate oxidoreductase, gamma subunit3e-1271.6
NC_020411:28995:364903649037170681Hydrogenobaculum sp. HO, complete genomepyruvate/ketoisovalerate oxidoreductase, gamma subunit3e-1271.6
NC_012438:565419:578924578924579604681Sulfurihydrogenibium azorense Az-Fu1 chromosome, complete genomesubunit of 2-oxoglutarate:ferredoxin oxidoredutase7e-1270.5
NC_010525:1360871:136087113608711361404534Thermoproteus neutrophilus V24Sta, complete genomepyruvate/ketoisovalerate oxidoreductase, gamma subunit2e-1168.6
NC_009515:307800:3141933141933156531461Methanobrevibacter smithii ATCC 35061, complete genome2-oxoisovalerate ferredoxin oxidoreductase, beta subunit5e-1064.3
NC_016776:3714642:3756623375662337601773555Bacteroides fragilis 638R, complete genomeputative pyruvate-flavodoxin oxidoreductase4e-0961.2
NC_003228:3690596:3710593371059337141473555Bacteroides fragilis NCTC 9343, complete genomeputative pyruvate-flavodoxin oxidoreductase4e-0961.2
NC_006347:3760447:3801887380188738054413555Bacteroides fragilis YCH46, complete genomepyruvate-flavodoxin oxidoreductase4e-0961.2
NC_010337:1188373:119503211950321195601570Heliobacterium modesticaldum Ice1, complete genome2-oxoacid:ferredoxin oxidoreductase, gamma subunit6e-0960.8
NC_013316:120759:156553156553157110558Clostridium difficile R20291, complete genomeputative subunit of oxidoreductase7e-0960.5
NC_009089:117980:161043161043161600558Clostridium difficile 630, complete genomeputative subunit of oxidoreductase7e-0960.5
NC_014121:1848971:1864006186400618675303525Enterobacter cloacae subsp. cloacae ATCC 13047 chromosome, completepyruvate flavodoxin/ferredoxin oxidoreductase domain-containing protein8e-0960.1
NC_014933:3688000:3698916369891637024733558Bacteroides helcogenes P 36-108 chromosome, complete genomepyruvate ferredoxin/flavodoxin oxidoreductase9e-0960.1
NC_015499:352934:369855369855370397543Thermodesulfobium narugense DSM 14796 chromosome, complete genomePyruvate/ketoisovalerate oxidoreductase9e-0960.1
NC_011653:331986:338461338461339000540Thermosipho africanus TCF52B, complete genome2-oxoglutarate oxidoreductase, gamma subunit1e-0859.3
NC_017297:3752000:376336837633683763898531Clostridium botulinum F str. 230613 chromosome, complete genome2-oxoglutarate ferredoxin oxidoreductase subunit gamma2e-0858.9
NC_015555:386000:395670395670396221552Thermoanaerobacterium xylanolyticum LX-11 chromosome, completepyruvate/ketoisovalerate oxidoreductase, gamma subunit3e-0858.5
NC_012658:3744000:375283837528383753368531Clostridium botulinum Ba4 str. 657 chromosome, complete genome3e-0858.5
NC_009698:3526359:353502035350203535550531Clostridium botulinum A str. Hall chromosome, complete genome2-oxoglutarate ferredoxin oxidoreductase subunit gamma3e-0858.5
NC_012563:3921859:392982639298263930356531Clostridium botulinum A2 str. Kyoto, complete genome2-oxoacid:acceptor oxidoreductase, gamma subunit, pyruvate/2-ketoisovalerate family3e-0858.5
NC_010516:3724312:373297537329753733505531Clostridium botulinum B1 str. Okra, complete genome2-oxoacid:acceptor oxidoreductase, gamma subunit, pyruvate/2-ketoisovalerate family3e-0858.5
NC_010520:3753875:376248937624893763019531Clostridium botulinum A3 str. Loch Maree, complete genome2-oxoacid:acceptor oxidoreductase, gamma subunit, pyruvate/2-ketoisovalerate family4e-0858.2
NC_012947:2366000:2366039236603923695633525Escherichia coli 'BL21-Gold(DE3)pLysS AG' chromosome, completepyruvate ferredoxin/flavodoxin oxidoreductase5e-0857.8
NC_016612:4119410:4120874412087441244013528Klebsiella oxytoca KCTC 1686 chromosome, complete genomeputative oxidoreductase, Fe-S subunit5e-0857.8
NC_016514:2476359:2476899247689924804233525Enterobacter cloacae EcWSU1 chromosome, complete genomepyruvate-flavodoxin oxidoreductase6e-0857.4
NC_008563:1505405:1523747152374715272713525Escherichia coli APEC O1, complete genomeprobable pyruvate-flavodoxin oxidoreductase5e-0857.4
NC_013192:374000:3900783900783936473570Leptotrichia buccalis DSM 1135, complete genomepyruvate ferredoxin/flavodoxin oxidoreductase5e-0857.4
NC_013740:571879:5718795718795753943516Acidaminococcus fermentans DSM 20731, complete genomepyruvate ferredoxin/flavodoxin oxidoreductase1e-0756.6
NC_013716:1756545:1756545175654517600693525Citrobacter rodentium ICC168, complete genomeprobable pyruvate-flavodoxin oxidoreductase2e-0755.5
NC_011149:1429523:1461503146150314650273525Salmonella enterica subsp. enterica serovar Agona str. SL483,pyruvate:ferredoxin (flavodoxin) oxidoreductase2e-0755.5
NC_011294:1465500:1483436148343614869603525Salmonella enterica subsp. enterica serovar Enteritidis strpyruvate-flavodoxin oxidoreductase3e-0755.1
NC_011769:2542000:254915525491552549697543Desulfovibrio vulgaris str. 'Miyazaki F', complete genomepyruvate ferredoxin/flavodoxin oxidoreductase3e-0755.1
NC_015761:1630000:1630384163038416339083525Salmonella bongori NCTC 12419, complete genomepyruvate-flavodoxin oxidoreductase4e-0754.7
NC_003366:2356148:2356148235614823596633516Clostridium perfringens str. 13, complete genomepyruvate ferredoxin oxidoreductase5e-0754.3
NC_008262:2242432:2242432224243222459473516Clostridium perfringens SM101, complete genomepyruvate-flavodoxin oxidoreductase6e-0753.9
NC_008346:36176:425024250243089588Syntrophomonas wolfei subsp. wolfei str. Goettingen, completeputative keto/oxoacid ferredoxin oxidoreductase, gamma subunit1e-0653.1
NC_020063:2449554:2449554244955424530813528Enterobacteriaceae bacterium strain FGI 57, complete genomepyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric1e-0653.1
NC_011565:620801:6288626288626324073546Candidatus Azobacteroides pseudotrichonymphae genomovar. CFP2,putative pyruvate-flavodoxin oxidoreductase1e-0653.1
NC_014355:781537:789752789752790465714Candidatus Nitrospira defluvii, complete genome2-oxoglutarate:ferredoxin oxidoredutase subunit gamma1e-0652.8
NC_015958:2206032:222869722286972229254558Thermoanaerobacter wiegelii Rt8.B1 chromosome, complete genomepyruvate/ketoisovalerate oxidoreductase subunit gamma2e-0652
NC_014011:527681:544088544088544654567Aminobacterium colombiense DSM 12261 chromosome, complete genomePyruvate/ketoisovalerate oxidoreductase3e-0651.6
NC_008800:2298000:2300090230009023036233534Yersinia enterocolitica subsp. enterocolitica 8081 chromosome,putative pyruvate-flavodoxin oxidoreductase5e-0651.2
NC_003454:2080705:2083445208344520870173573Fusobacterium nucleatum subsp. nucleatum ATCC 25586, completePyruvate-flavodoxin oxidoreductase4e-0651.2
NC_010674:2435241:2441466244146624449813516Clostridium botulinum B str. Eklund 17B, complete genomepyruvate:ferredoxin (flavodoxin) oxidoreductase4e-0651.2
NC_010723:2231834:2238940223894022424583519Clostridium botulinum E3 str. Alaska E43, complete genomepyruvate:ferredoxin (flavodoxin) oxidoreductase5e-0650.8
NC_014537:222114:223516223516223959444Vulcanisaeta distributa DSM 14429 chromosome, complete genomePyruvate/ketoisovalerate oxidoreductase6e-0650.4
NC_014538:1942500:194811319481131948670558Thermoanaerobacter sp. X513 chromosome, complete genomepyruvate/ketoisovalerate oxidoreductase subunit gamma7e-0650.4