Pre_GI: BLASTP Hits

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Query: NC_004557:2677155:2684772 Clostridium tetani E88, complete genome

Start: 2684772, End: 2685077, Length: 306

Host Lineage: Clostridium tetani; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain is a virulent nonsporulating variant of strain Massachusetts used in vaccine production. Causes tetanus. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. Known opportunistic toxin-producing pathogens in animals and humans. Some species are capable of producing organic solvents (acetone, ethanol, etc,), molecular hydrogen and other useful compounds. This organism causes tetanus (lockjaw) in humans. At the tissue level, the bacterium then releases an exotoxin called tetanospasmin that causes certain nervous system irregularities by means of retrograde tramsmission through neurons to the brain. If nervous impulses cannot be checked by normal inhibitory mechanisms, it produces the generalized muscular spasms characteristic of tetanus.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_008593:1797000:179919117991911799493303Clostridium novyi NT, complete genomepyruvate synthase subunit porD1e-37155
NC_019978:39000:481414814148422282Halobacteroides halobius DSM 5150, complete genome2-oxoacid:acceptor oxidoreductase, delta subunit, pyruvate/2-ketoisovalerate family2e-22104
NC_015499:491423:494270494270494629360Thermodesulfobium narugense DSM 14796 chromosome, complete genomepyruvate ferredoxin/flavodoxin oxidoreductase, delta subunit3e-1890.5
NC_010730:627465:629711629711630016306Sulfurihydrogenibium sp. YO3AOP1, complete genomepyruvate ferredoxin/flavodoxin oxidoreductase, delta subunit5e-1889.7
NC_016751:1623756:163381316338131634121309Marinitoga piezophila KA3 chromosome, complete genome2-oxoacid:acceptor oxidoreductase subunit delta, pyruvate/2-ketoisovalerate family2e-1787.8
NC_015474:1185478:119274211927421193059318Pyrococcus sp. NA2 chromosome, complete genomepyuvate ferredoxin oxidoreductase subunit delta5e-1786.3
NC_000961:597385:606773606773607099327Pyrococcus horikoshii OT3, complete genomeferredoxin oxidoreductase delta subunit1e-1685.1
NC_003413:916398:927581927581927898318Pyrococcus furiosus DSM 3638, complete genomepyruvate ferredoxin oxidoreductase subunit delta1e-1684.7
NC_003413:916398:930085930085930402318Pyrococcus furiosus DSM 3638, complete genome2-ketovalerate ferredoxin oxidoreductase subunit delta-22e-1477.8
NC_003901:1568000:160526616052661605598333Methanosarcina mazei Go1, complete genomepyruvate synthase delta subunit6e-1476.3
NC_020389:1346358:137774413777441378076333Methanosarcina mazei Tuc01, complete genomePyruvate:ferredoxin oxidoreductase, Delta subunit6e-1476.3
NC_015474:1185478:119023911902391190556318Pyrococcus sp. NA2 chromosome, complete genome2-ketoisovalerate ferredoxin oxidoreductase subunit delta9e-1475.5
NC_000961:597385:604298604298604615318Pyrococcus horikoshii OT3, complete genomeferredoxin oxidoreductase delta subunit1e-1375.1
NC_015320:1342105:137693713769371377191255Archaeoglobus veneficus SNP6 chromosome, complete genomepyruvate ferredoxin/flavodoxin oxidoreductase subunit delta3e-1373.9
NC_009635:1322860:134213113421311342391261Methanococcus aeolicus Nankai-3 chromosome, complete genomepyruvate ferredoxin/flavodoxin oxidoreductase subunit delta5e-1373.2
NC_014537:663216:677455677455677808354Vulcanisaeta distributa DSM 14429 chromosome, complete genomepyruvate ferredoxin/flavodoxin oxidoreductase subunit delta4e-1270.1
NC_013926:289511:297334297334297660327Aciduliprofundum boonei T469 chromosome, complete genomepyruvate ferredoxin/flavodoxin oxidoreductase, delta subunit1e-1168.6
NC_002754:2505750:251375625137562514040285Sulfolobus solfataricus P2, complete genomePyruvate synthase delta chain (Pyruvic-ferredoxin oxidoreductase delta chain) (porD-2)1e-1065.1
NC_009051:657000:689468689468689728261Methanoculleus marisnigri JR1, complete genomepyruvate ferredoxin/flavodoxin oxidoreductase, delta subunit2e-1064.3
NC_014314:576465:592614592614592910297Dehalogenimonas lykanthroporepellens BL-DC-9 chromosome, completepyruvate ferredoxin/flavodoxin oxidoreductase subunit delta5e-1063.2
NC_009464:2288500:230143023014302301717288Uncultured methanogenic archaeon RC-I, complete genomepyruvate:ferredoxin oxidoreductase, delta subunit2e-0961.2
NC_013769:316789:326040326040326309270Sulfolobus islandicus L.D.8.5 chromosome, complete genomepyruvate ferredoxin/flavodoxin oxidoreductase subunit delta4e-0960.1
NC_012623:2369671:237870623787062378975270Sulfolobus islandicus Y.N.15.51 chromosome, complete genomepyruvate ferredoxin/flavodoxin oxidoreductase subunit delta4e-0960.1
NC_012622:327821:332559332559332828270Sulfolobus islandicus Y.G.57.14 chromosome, complete genomepyruvate ferredoxin/flavodoxin oxidoreductase subunit delta4e-0960.1
NC_016627:3158353:316406531640653164376312Clostridium clariflavum DSM 19732 chromosome, complete genome2-oxoacid:acceptor oxidoreductase, delta subunit, pyruvate/2-ketoisovalerate family4e-0960.1
NC_000921:1147394:114891511489151149307393Helicobacter pylori J99, complete genomePyruvate ferrodoxin oxidoreductase6e-0959.7
NC_017276:320000:329676329676329942267Sulfolobus islandicus REY15A chromosome, complete genomepyruvate ferredoxin/flavodoxin oxidoreductase subunit delta6e-0959.7
NC_015275:4577642:458503445850344585351318Clostridium lentocellum DSM 5427 chromosome, complete genomepyruvate ferredoxin/flavodoxin oxidoreductase, delta subunit2e-0858.2
NC_007759:2179000:218245321824532182704252Syntrophus aciditrophicus SB, complete genomepyruvate synthase delta subunit3e-0857.4
NC_009437:2367842:2382617238261723836361020Caldicellulosiruptor saccharolyticus DSM 8903, complete genomepyruvate/ketoisovalerate oxidoreductase, gamma subunit4e-0856.6
NC_014392:969498:9944539944539954721020Caldicellulosiruptor obsidiansis OB47 chromosome, complete genomepyruvate/ketoisovalerate oxidoreductase, gamma subunit4e-0856.6
NC_012034:1783912:1798859179885917998781020Anaerocellum thermophilum DSM 6725, complete genomepyruvate/ketoisovalerate oxidoreductase, gamma subunit1e-0755.5
NC_014657:1518721:1534016153401615350351020Caldicellulosiruptor owensensis OL chromosome, complete genomepyruvate/ketoisovalerate oxidoreductase, gamma subunit1e-0755.5
NC_009943:1637582:165578616557861656085300Candidatus Desulfococcus oleovorans Hxd3, complete genomepyruvate ferredoxin/flavodoxin oxidoreductase, delta subunit2e-0754.7
NC_014721:1777644:1792478179247817934971020Caldicellulosiruptor kristjanssonii 177R1B chromosome, completepyruvate/ketoisovalerate oxidoreductase, gamma subunit2e-0754.7
NC_015949:1180755:1195574119557411965931020Caldicellulosiruptor lactoaceticus 6A chromosome, complete genomepyruvate/ketoisovalerate oxidoreductase subunit gamma2e-0754.3
NC_014652:1032711:1059267105926710602861020Caldicellulosiruptor hydrothermalis 108 chromosome, completepyruvate/ketoisovalerate oxidoreductase, gamma subunit2e-0754.3
NC_014720:1161841:1166638116663811676571020Caldicellulosiruptor kronotskyensis 2002 chromosome, completepyruvate/ketoisovalerate oxidoreductase, gamma subunit3e-0753.9
NC_007644:362000:381404381404381673270Moorella thermoacetica ATCC 39073, complete genome2-oxoacid:acceptor oxidoreductase, delta subunit, pyruvate/2-ketoisovalerate4e-0753.5