Pre_GI: BLASTP Hits

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Query: NC_004088:1622941:1637328 Yersinia pestis KIM, complete genome

Start: 1637328, End: 1637534, Length: 207

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Causative agent of plague. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_017168:2394079:240474924047492404955207Yersinia pestis A1122 chromosome, complete genomehypothetical protein9e-34142
NC_017265:1346685:135650413565041356695192Yersinia pestis biovar Medievalis str. Harbin 35 chromosome,hypothetical protein1e-30131
NC_009381:2373847:238274923827492382940192Yersinia pestis Pestoides F chromosome, complete genomehypothetical protein1e-30131
NC_008149:1556581:156726615672661567457192Yersinia pestis Nepal516, complete genomehypothetical protein1e-30131
NC_008150:2451872:246214924621492462340192Yersinia pestis Antiqua, complete genomehypothetical protein1e-30131
NC_010159:2878499:288740128874012887592192Yersinia pestis Angola, complete genome7e-30129
NC_009708:1522281:1530429153042915316491221Yersinia pseudotuberculosis IP 31758 chromosome, complete genomepeptidase3e-24110
NC_010465:1550617:1565032156503215662521221Yersinia pseudotuberculosis YPIII, complete genomepeptidase M243e-24110
NC_006155:3212796:3220670322067032218901221Yersinia pseudotuberculosis IP 32953, complete genomeputative peptidase3e-24110
NC_010634:3129174:3138423313842331396431221Yersinia pseudotuberculosis PB1/+, complete genomepeptidase M243e-24110