Pre_GI: BLASTP Hits

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Query: NC_003997:3414441:3419412 Bacillus anthracis str. Ames, complete genome

Start: 3419412, End: 3419852, Length: 441

Host Lineage: Bacillus anthracis; Bacillus; Bacillaceae; Bacillales; Firmicutes; Bacteria

General Information: This well studied laboratory strain (Porton isolate) is not virulent due to the loss of the two plasmids, pXO1 and pXO2. Under starvation conditions this group of bacteria initiate a pathway that leads to endospore formation, a process that is thoroughly studied and is a model system for prokaryotic development and differentiation. Spores are highly resistant to heat, cold, dessication, radiation, and disinfectants, and enable the organism to persist in otherwise inhospitable environments. Under more inviting conditions the spores germinate to produce vegetative cells. This organism was the first to be shown to cause disease by Dr. Louis Pasteur (the organism, isolated from sick animals, was grown in the laboratory and then used to infect healthy animals and make them sick). This organism was also the first for which an attenuated strain was developed as a vaccine. Herbivorous animals become infected with the organism when they ingest spores from the soil whereas humans become infected when they come into contact with a contaminated animal. PA/LF and PA/EF complexes are internalized by host cells where the LF (metalloprotease) and EF (calmodulin-dependent adenylate cyclase) components act. At high levels LF induces cell death and release of the bacterium while EF increases host susceptibility to infection and promotes fluid accumulation in the cells.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_016779:3418538:343154134315413431981441Bacillus cereus F837/76 chromosome, complete genomehypothetical protein2e-71266
NC_008600:3488000:349091534909153491355441Bacillus thuringiensis str. Al Hakam, complete genomehypothetical protein2e-71266
NC_012472:3503000:350587835058783506318441Bacillus cereus 03BB102, complete genomehypothetical protein2e-71266
NC_006274:3490598:349336034933603493800441Bacillus cereus E33L, complete genomehypothetical protein2e-71266
NC_005957:3488021:349080434908043491244441Bacillus thuringiensis serovar konkukian str. 97-27, completehypothetical protein2e-71266
NC_005945:3415135:342010634201063420546441Bacillus anthracis str. Sterne, complete genomehypothetical protein2e-71266
NC_007530:3414568:341953934195393419979441Bacillus anthracis str. 'Ames Ancestor', complete genomehypothetical protein2e-71266
NC_014335:3408081:341239334123933412833441Bacillus cereus biovar anthracis str. CI chromosome, completehypothetical protein2e-71266
NC_011658:3438102:344086734408673441307441Bacillus cereus AH187 chromosome, complete genomehypothetical protein2e-71266
NC_011773:3496873:350118435011843501624441Bacillus cereus AH820 chromosome, complete genomehypothetical protein2e-71266
NC_012581:803456:818759818759819199441Bacillus anthracis str. CDC 684 chromosome, complete genomehypothetical protein2e-71266
NC_012659:3416000:341943934194393419879441Bacillus anthracis str. A0248, complete genomehypothetical protein2e-71266
NC_016771:3386660:339336533933653393805441Bacillus cereus NC7401, complete genomehypothetical protein2e-71266
NC_003909:3432073:343483634348363435276441Bacillus cereus ATCC 10987, complete genomehypothetical protein3e-70263
NC_017200:3501500:350434835043483504788441Bacillus thuringiensis serovar finitimus YBT-020 chromosome,hypothetical protein7e-69258
NC_011969:3401916:340471134047113405121411Bacillus cereus Q1 chromosome, complete genomehypothetical protein2e-62237