Query: NC_019962:2189432 Natrinema pellirubrum DSM 15624, complete genome
Lineage: Natrinema pellirubrum; Natrinema; Halobacteriaceae; Halobacteriales; Euryarchaeota; Archaea
General Information: Country: Italy; Isolation: Red heat in salted hides (spoiled fish); Temp: Mesophile. Natrinema pellirubrum, formerly Halobacterium salinarium is a halophilic archaea requiring at least 1.7 M NaCl for growth and able to grow at salt concentrations of up to 4.3 M.
Subject: NC_015571:2273503 Porphyromonas gingivalis TDC60, complete genome
Lineage: Porphyromonas gingivalis; Porphyromonas; Porphyromonadaceae; Bacteroidales; Bacteroidetes; Bacteria
General Information: This organism is associated with severe and chronic periodontal (tissues surrounding and supporting the tooth) diseases. Progression of the disease is caused by colonization by this organism in an anaerobic environment in host tissues and severe progression results in loss of the tissues supporting the tooth and eventually loss of the tooth itself. The black pigmentation characteristic of this bacterium comes from iron acquisition that does not use the typical siderophore system of other bacteria but accumulates hemin. Peptides appear to be the predominant carbon and energy source of this organism, perhaps in keeping with its ability to destroy host tissue. Oxygen tolerance systems play a part in establishment of the organism in the oral cavity, including a superoxide dismutase. Pathogenic factors include extracellular adhesins that mediate interactions with other bacteria as well as the extracellular matrix, and a host of degradative enzymes that are responsible for tissue degradation and spread of the organism including the gingipains, which are trypsin-like cysteine proteases.