Query: NC_019960:260997 Prevotella dentalis DSM 3688 chromosome 1, complete sequence Lineage: Prevotella dentalis; Prevotella; Prevotellaceae; Bacteroidales; Bacteroidetes; Bacteria General Information: Environment: Host, Human oral microflora; Isolation: Human dental root canal; Temp: Mesophile; Temp: 37C. This organism is an member of the human oral microbial community that has been isolated in association with infections of the dental root canal.
- Sequence; - BLASTP hit: hover for score (Low score = Light, High score = Dark); - hypothetical protein; - cds: hover for description
General Information: This strain was isolated from a human skin biopsy in Brazil, and passaged in nude mice and armadillos. The bacterium is a close relative of M. tuberculosis. However, compared to the latter, the genome of M. leprae is smaller due to reductive genome evolution, with many important metabolic activities including siderophore production, part of the oxidative chain, most of the microaerophilic and anaerobic respiratory chains, and numerous catabolic systems and their regulatory circuits eliminated due to extensive recombination events between dispersed repetitive sequences. It is evident that this species has undergone massive genome reduction over time as a result of its parasitic nature, discarding more than half its genes and rendering it the most striking example of genome reduction in a microbial pathogen.