Query: NC_018720:47984 Bifidobacterium asteroides PRL2011 chromosome, complete genome Lineage: Bifidobacterium asteroides; Bifidobacterium; Bifidobacteriaceae; Bifidobacteriales; Actinobacteria; Bacteria General Information: Bifidobacterium asteroides (strain PRL2011) is an aerobic, Gram-positive bacterium isolated from the hindgut of Apis mellifera var. ligustica, commonly known as the honey bee.
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General Information: Isolated from a patient with fever and lymphadenitis. Chronic granulomatous disease (CGD) is a rare inherited disease of the phagocyte NADPH oxidase system causing defective production of toxic oxygen metabolites, impaired bacterial and fungal killing, and recurrent life-threatening infections. This species was isolated from a 39 year old man with CGD and was shown to be the causal agent of the disease by classical methods. The isolation of this organism is the first known case of a bacterium from the Acetobacteraceae family to be the cause of an invasive human disease.