Query: NC_018664:3009166 Clostridium acidurici 9a chromosome, complete genome Lineage: Gottschalkia acidurici; Gottschalkia; ; Clostridiales; Firmicutes; Bacteria General Information: Clostridium acidiurici is an obligate anaerobic Gram-positive bacterium that is motile and spore-forming. It can be isolated from almost every soil but can also be found in the intestinal tract of birds. It is able to use purines like uric acid as sole carbon, nitrogen and energy source to build ammonia, carbon dioxide and acetic acid. Unlike most other Clostridia it is a specialist and not able to grow on sugars or different other substrates than purines.
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General Information: This organism is the causative agent of Glasser's disease in swine but is usually found as a commensal organism in the upper respiratory tract. Glasser's disease is responsible for significant losses in swine husbandry. The disease was first noted in 1910 by Glasser and the organism requires factor V (NAD - nicotinamide adenine dinucleotide) growth factor, like H. suis, but not factor X (iron porphyrin) which H. suis requires. Pathogenicity and virulence are often strain specific. Symptoms include fibrinous polyserositis (fibrous inflammation of serous membranes, polyarthritis (inflammation of multiple joints) and meningitis (inflammation of meninges)and pneumonia.