Pre_GI: SWBIT SVG BLASTP

Query: NC_018080:5192264 Pseudomonas aeruginosa DK2 chromosome, complete genome

Lineage: Pseudomonas aeruginosa; Pseudomonas; Pseudomonadaceae; Pseudomonadales; Proteobacteria; Bacteria

General Information: Bacteria belonging to the Pseudomonas group are common inhabitants of soil and water and can also be found on the surfaces of plants and animals. Pseudomonas bacteria are found in nature in a biofilm or in planktonic form. Pseudomonas bacteria are renowned for their metabolic versatility as they can grow under a variety of growth conditions and do not need any organic growth factors. This organism is an opportunistic human pathogen. While it rarely infects healthy individuals, immunocompromised patients, like burn victims, AIDS-, cancer- or cystic fibrosis-patients are at increased risk for infection with this environmentally versatile bacteria. It is an important soil bacterium with a complex metabolism capable of degrading polycyclic aromatic hydrocarbons, and producing interesting, biologically active secondary metabolites including quinolones, rhamnolipids, lectins, hydrogen cyanide, and phenazines. Production of these products is likely controlled by complex regulatory networks making Pseudomonas aeruginosa adaptable both to free-living and pathogenic lifestyles. The bacterium is naturally resistant to many antibiotics and disinfectants, which makes it a difficult pathogen to treat.

Subject: NC_001263:72681 Deinococcus radiodurans R1 chromosome 1, complete sequence

Lineage: Deinococcus radiodurans; Deinococcus; Deinococcaceae; Deinococcales; Deinococcus-Thermus; Bacteria

General Information: This red-pigmented organism's name means "strange berry that withstands radiation", marking the fact that this organism is one of the most radiation-resistant known. It can tolerate radiation levels at 1000 times the levels that would kill a human and it was originally isolated in 1956 from a can of meat that had been irradiated with X-rays. The resistance to radiation may reflect its resistance to dessication, which also causes DNA damage. This organism may be of use in cleaning up toxic metals found at nuclear weapons production sites due to the radiation resistance. This bacterium is also a highly efficient transformer, and can readily take up exogenous DNA from the environment, which may also aid DNA repair. This organism carries multiple copies of many DNA repair genes, suggesting a robust system for dealing with DNA damage. The recombination system may rely on multiple copies of various repeat elements found throughout the genome.