Pre_GI: SWBIT SVG BLASTP

Query: NC_017518:150991 Neisseria meningitidis NZ-05/33 chromosome, complete genome

Lineage: Neisseria meningitidis; Neisseria; Neisseriaceae; Neisseriales; Proteobacteria; Bacteria

General Information: The second of two pathogenic Neisseria, this organism causes septicemia and is the leading cause of life-threatening meningitis (inflammation of the meninges, the membrane surrounding the brain and spinal cord) in children. This organism typically residies in the nasopharynx cavity but can invade the respiratory epthelial barrier, cross into the bloodstream and the blood brain barrier, and cause inflammation of the meninges. Pathogenicity factors include the surface proteins (porins and opacity proteins), and the type IV pilus (which is also found in Neisseria gonorrhoeae). This organism, like Neisseria gonorrhoeae, is naturally competent, and protein complexes at the cell surface recognize the uptake signal sequence in extracellular DNA, an 8mer that is found at high frequency in Neisseria chromosomal DNA.

Subject: NC_002967:800109 Treponema denticola ATCC 35405, complete genome

Lineage: Treponema denticola; Treponema; Spirochaetaceae; Spirochaetales; Spirochaetes; Bacteria

General Information: Treponema denticola ATCC 35405 was isolated from a human periodontal pocket. Associated with periodontal disease. This organism is a member of the spirochaetales and is a motile, slender, helically shaped flexible organism. Obligately anaerobic growth occurs at 30-42°C, with a pH of 6.5-8.0. The bacterium is commonly found in the oral cavity of humans and often associated with periodontal disease, an inflammation of the gum tissue that frequently precedes bone resorbtion and subsequent tooth loss.