Pre_GI: SWBIT SVG BLASTP

Query: NC_017516:917817 Neisseria meningitidis H44/76 chromosome, complete genome

Lineage: Neisseria meningitidis; Neisseria; Neisseriaceae; Neisseriales; Proteobacteria; Bacteria

General Information: The second of two pathogenic Neisseria, this organism causes septicemia and is the leading cause of life-threatening meningitis (inflammation of the meninges, the membrane surrounding the brain and spinal cord) in children. This organism typically residies in the nasopharynx cavity but can invade the respiratory epthelial barrier, cross into the bloodstream and the blood brain barrier, and cause inflammation of the meninges. Pathogenicity factors include the surface proteins (porins and opacity proteins), and the type IV pilus (which is also found in Neisseria gonorrhoeae). This organism, like Neisseria gonorrhoeae, is naturally competent, and protein complexes at the cell surface recognize the uptake signal sequence in extracellular DNA, an 8mer that is found at high frequency in Neisseria chromosomal DNA.

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BLASTP Alignment.txt

Subject: NC_014752:1063506 Neisseria lactamica ST-640, complete genome

Lineage: Neisseria lactamica; Neisseria; Neisseriaceae; Neisseriales; Proteobacteria; Bacteria

General Information: Neisseria lactamica ST-640 was isolated from a nasopharyngeal culture. This organism is a nonpathogenic, commensal, bacterium closely related to the pathogenic Neisseria meningitidis. While commonly isolated from nose and throat cultures of children Neisseria lactamica is only rarely isolated from adults.