Pre_GI: SWBIT SVG BLASTP

Query: NC_017515:1855114 Neisseria meningitidis M04-240196 chromosome, complete genome

Lineage: Neisseria meningitidis; Neisseria; Neisseriaceae; Neisseriales; Proteobacteria; Bacteria

General Information: The second of two pathogenic Neisseria, this organism causes septicemia and is the leading cause of life-threatening meningitis (inflammation of the meninges, the membrane surrounding the brain and spinal cord) in children. This organism typically residies in the nasopharynx cavity but can invade the respiratory epthelial barrier, cross into the bloodstream and the blood brain barrier, and cause inflammation of the meninges. Pathogenicity factors include the surface proteins (porins and opacity proteins), and the type IV pilus (which is also found in Neisseria gonorrhoeae). This organism, like Neisseria gonorrhoeae, is naturally competent, and protein complexes at the cell surface recognize the uptake signal sequence in extracellular DNA, an 8mer that is found at high frequency in Neisseria chromosomal DNA.

Subject: NC_008358:798390 Hyphomonas neptunium ATCC 15444, complete genome

Lineage: Hyphomonas neptunium; Hyphomonas; Hyphomonadaceae; Rhodobacterales; Proteobacteria; Bacteria

General Information: Marine member of dimorphic prosthecate bacteria. This organism is also known as Hyphomicrobium neptunium. It has a biphasic life style, which consists of a motile phase of flagellated swarmer cells, and a cessile phase in which a long prosthecate is produced at one end of the bacteria through which budding cells emerge. Newly budded cells in turn produce flagella and go through a motile phase and the cycle continues. These organisms can colonize the surfaces of marine environments which enables additional species to colonize at later stages. This organism may be of use in treatment of water as they attach to a solid surface and are capable of degradation of a number of pollutants including aromatic hydrocarbons, dimethyl sulfoxide and methyl chloride.