Query: NC_017512:2161000 Neisseria meningitidis WUE 2594, complete genome Lineage: Neisseria meningitidis; Neisseria; Neisseriaceae; Neisseriales; Proteobacteria; Bacteria General Information: The second of two pathogenic Neisseria, this organism causes septicemia and is the leading cause of life-threatening meningitis (inflammation of the meninges, the membrane surrounding the brain and spinal cord) in children. This organism typically residies in the nasopharynx cavity but can invade the respiratory epthelial barrier, cross into the bloodstream and the blood brain barrier, and cause inflammation of the meninges. Pathogenicity factors include the surface proteins (porins and opacity proteins), and the type IV pilus (which is also found in Neisseria gonorrhoeae). This organism, like Neisseria gonorrhoeae, is naturally competent, and protein complexes at the cell surface recognize the uptake signal sequence in extracellular DNA, an 8mer that is found at high frequency in Neisseria chromosomal DNA.
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General Information: Isolated from canned milk from the USA. Aquatic organism that can cause foodborne illnesses in humans. This organism is an enviromental bacterium that is often found in aquatic habitats, but can also be found contaminating food products. It causes a variety of diseases in both cold-blooded and warm-blooded organisms. The bacterium is becoming a problematic pathogen in humans, where it causes gastroenteritis and septicemia, mainly due to the development of antibiotic resistance by this organism. One of the major virulence factors is aerolysin, a toxin that is produced and secreted by the cell via a type II secretion apparatus. Other virulence functions include a surface layer which inhibits complement-mediated killing, type IV pili for attachment, and a set of extracellular proteases which can cause tissue damage.