Pre_GI: SWBIT SVG BLASTP

Query: NC_017512:2116295 Neisseria meningitidis WUE 2594, complete genome

Lineage: Neisseria meningitidis; Neisseria; Neisseriaceae; Neisseriales; Proteobacteria; Bacteria

General Information: The second of two pathogenic Neisseria, this organism causes septicemia and is the leading cause of life-threatening meningitis (inflammation of the meninges, the membrane surrounding the brain and spinal cord) in children. This organism typically residies in the nasopharynx cavity but can invade the respiratory epthelial barrier, cross into the bloodstream and the blood brain barrier, and cause inflammation of the meninges. Pathogenicity factors include the surface proteins (porins and opacity proteins), and the type IV pilus (which is also found in Neisseria gonorrhoeae). This organism, like Neisseria gonorrhoeae, is naturally competent, and protein complexes at the cell surface recognize the uptake signal sequence in extracellular DNA, an 8mer that is found at high frequency in Neisseria chromosomal DNA.

Subject: NC_011653:1226035 Thermosipho africanus TCF52B, complete genome

Lineage: Thermosipho africanus; Thermosipho; Thermotogaceae; Thermotogales; Thermotogae; Bacteria

General Information: This organism was isolated from the Troll oil formation in the North Sea. Thermosipho africanus, a member of the Thermotogales, has the characteristic morphology of one or more cells contained in a sheath-like envelope which extends beyond the cell wall. Preliminary sequencing of Thermotogales genomes has identified extensive horizontal gene transfer between these organisms and the Archaea. Thermosipho africanus has been isolated from marine hydrothermal systems and oil reservoir production waters.