Pre_GI: SWBIT SVG BLASTP

Query: NC_017353:1750971 Staphylococcus lugdunensis N920143, complete genome

Lineage: Staphylococcus lugdunensis; Staphylococcus; Staphylococcaceae; Bacillales; Firmicutes; Bacteria

General Information: Staphylococcus lugdunensis is known to be a pathogenic member of the coagulase-negative staphylococci, causing skin and soft tissue infections, catheter-related bacteremia, native valve endocardititis and osteomyelitis.

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BLASTP Alignment.txt

Subject: NC_003997:3617000 Bacillus anthracis str. Ames, complete genome

Lineage: Bacillus anthracis; Bacillus; Bacillaceae; Bacillales; Firmicutes; Bacteria

General Information: This well studied laboratory strain (Porton isolate) is not virulent due to the loss of the two plasmids, pXO1 and pXO2. Under starvation conditions this group of bacteria initiate a pathway that leads to endospore formation, a process that is thoroughly studied and is a model system for prokaryotic development and differentiation. Spores are highly resistant to heat, cold, dessication, radiation, and disinfectants, and enable the organism to persist in otherwise inhospitable environments. Under more inviting conditions the spores germinate to produce vegetative cells. This organism was the first to be shown to cause disease by Dr. Louis Pasteur (the organism, isolated from sick animals, was grown in the laboratory and then used to infect healthy animals and make them sick). This organism was also the first for which an attenuated strain was developed as a vaccine. Herbivorous animals become infected with the organism when they ingest spores from the soil whereas humans become infected when they come into contact with a contaminated animal. PA/LF and PA/EF complexes are internalized by host cells where the LF (metalloprotease) and EF (calmodulin-dependent adenylate cyclase) components act. At high levels LF induces cell death and release of the bacterium while EF increases host susceptibility to infection and promotes fluid accumulation in the cells.