Pre_GI: SWBIT SVG BLASTP

Query: NC_017328:2785309 Shigella flexneri 2002017 chromosome, complete genome

Lineage: Shigella flexneri; Shigella; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This organism, along with Shigella sonnei, is the major cause of shigellosis in industrialized countries and is responsible for endemic infections. This genus is named for the Japanese scientist (Shiga) who discovered them in the 1890s. They are closely related to the Escherichia group, and may be considered the same species. Human-specific pathogens that are transmitted via contaminated food and water and are the leading causes of endemic bacillary dysentery, and over 1 million deaths worldwide are attributed to them. The bacteria infect the epithelial lining of the colon, causing acute inflammation by entering the host cell cytoplasm and spreading intercellularly. Extremely virulent organisms that require very few cells in order to cause disease. Both the type III secretion system, which delivers effector molecules into the host cell, and some of the translocated effectors such as the invasion plasmid antigens (Ipas), are encoded on the plasmid. The bacterium produces a surface protein that localizes to one pole of the cell (IcsA) which binds to and promotes actin polymerization, resulting in movement of the bacterium through the cell cytoplasm, and eventually to neighboring cells, which results in inflammatory destruction of the mucosal lining.

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BLASTP Alignment.txt

Subject: NC_015857:1609670 Brucella pinnipedialis B2/94 chromosome chromosome 1, complete

Lineage: Brucella pinnipedialis; Brucella; Brucellaceae; Rhizobiales; Proteobacteria; Bacteria

General Information: Brucella pinnipedialis has been isolated from seals, porpoises and other marine mammals. This organism can be isolated from skin, blood, spleen and lymph nodes although the pathogenesis of this organism has yet to be determined.