Query: NC_017246:528825 Brucella melitensis M5-90 chromosome chromosome I, complete Lineage: Brucella melitensis; Brucella; Brucellaceae; Rhizobiales; Proteobacteria; Bacteria General Information: They are highly infectious, and can be spread through contact with infected animal products or through the air, making them a potential bioterrorism agent. Once the organism has entered the body, it can become intracellular, and enter the blood and lymphatic regions, multiplying inside phagocytes before eventually causing bacteremia (spread of bacteria through the blood). Virulence may depend on a type IV secretion system which may promote intracellular growth by secreting important effector molecules. This organism is a facultative intracellular bacteria that causes abortion in wild and domestic animals, usually goats or sheep, and undulant fever in humans. Brucellosis is a major health problem in the Mediterranean region and parts of Asia, Africa, and Latin America, where it causes severe economic losses. The disease is transmitted to humans by nonpasteurized milk and milk products or by direct contact with infected animals or carcasses.
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General Information: This strain was isolated from an iron-rich microbial mat from School Street Marsh in Woods Hole, MA, USA. It grows photoautotrophically with Fe(II), H2, or thiosulfate as the electron donor, photoheterotrophically with a variety of organic carbon sources and chemoheterotrophically in the dark. This organism has a diverse metabolism and is capable of growth using light, inorganic, or organic compounds as energy sources and carbon dioxide or organic compounds as carbon sources. Commonly found in soil and water environments this bacterium is also capable of degrading a wide range of toxic organic compounds, and may be of use in bioremediation of polluted sites. The bacterium undergoes differentiation to produce a stalked nonmotile cell and a motile flagellated cell. In the presence of light, this bacterium produces a number of intracellular membranous vesicles to house the photosynthetic reaction centers.