Pre_GI: SWBIT SVG BLASTP

Query: NC_017168:2281040 Yersinia pestis A1122 chromosome, complete genome

Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

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BLASTP Alignment.txt

Subject: NC_011979:2352961 Geobacter sp. FRC-32, complete genome

Lineage: Geobacter daltonii; Geobacter; Geobacteraceae; Desulfuromonadales; Proteobacteria; Bacteria

General Information: This organism is able to reduce uranium and may be useful for in situ bioremediation of uranium. An iron(III)-reducing bacterium isolated from the uranium-contaminated subsurface of the U.S. Department of Energy NABIR Field Research Center (FRC), Oak Ridge, Tennessee, USA. Several recent studies have verified using cultivation-independent methods that the Geobacteraceae are predominant in subsurface environments where dissimilatory metal reduction is important to the remediation of uranium and other contaminants.