Pre_GI: SWBIT SVG BLASTP

Query: NC_017160:1507500 Yersinia pestis D182038 chromosome, complete genome

Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

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BLASTP Alignment.txt

Subject: NC_012691:2476223 Tolumonas auensis DSM 9187, complete genome

Lineage: Tolumonas auensis; Tolumonas; Aeromonadaceae; Aeromonadales; Proteobacteria; Bacteria

General Information: Isolation: freshwater mud; Temp: Mesophile; Habitat: Fresh water, Mud; Isolation: sediment of freshwater lake; Country:Switzerland. Tolumonas auensis is able to produce the aromatic hydrocarbon tolulene when grown on phenylalanine, phenyllactate,and phenylpyruvate with a separate carbon source. This organism can also produce tyrosines when grown with phenol.