Query: NC_017095:1333810 Fervidobacterium pennivorans DSM 9078 chromosome, complete genome Lineage: Fervidobacterium pennivorans; Fervidobacterium; Thermotogaceae; Thermotogales; Thermotogae; Bacteria General Information: Country: Italy; Environment: Hot spring, Mud, Sediment; Isolation: hot mud of spa; Temp: Thermophile; Temp: 65C. This organism is an extreme thermophilic member of the Thermotogales and has the characteristic morphology of one or more cells contained in a sheath-like envelope which extends beyond the cell wall. This organism produces a protease which is able to degrade keratin.
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General Information: This strain is an egg-passaged attentuated avirulent strain that has been used as a live vaccine and was originally isolated from a typhus patient in Madrid. This species is the causal agent of typhus. The bacteria are transmitted via an insect, usually a tick, to a host organism, in this case humans, where they target endothelial cells and sometimes macrophages. They attach via an adhesin, rickettsial outer membrane protein A, and are internalized where they persist as cytoplasmically free organisms. Transovarial transmission (from mother to offspring) occurs in the invertebrate host.