Pre_GI: SWBIT SVG BLASTP

Query: NC_017062:33268 Rickettsia typhi str. B9991CWPP chromosome, complete genome

Lineage: Rickettsia typhi; Rickettsia; Rickettsiaceae; Rickettsiales; Proteobacteria; Bacteria

General Information: This genus, like other Rickettsial organisms such as Neorickettsia and Anaplasma, is composed of obligate intracellular pathogens. The latter is composed of two organisms, Rickettsia prowazekii and Rickettsia typhi. The bacteria are transmitted via an insect, usually a tick, to a host organism, in this case humans, where they target endothelial cells and sometimes macrophages. They attach via an adhesin, rickettsial outer membrane protein A, and are internalized where they persist as cytoplasmically free organisms. Transovarial transmission (from mother to offspring) occurs in the invertebrate host. This organism causes murine typhus and is an obligate intracellular pathogen that infects both the flea vector and hosts such as human, rat, and mouse. R. prowazekii, and genomic comparisons demonstrate colinearity and similarity to the genome of that organism except for two independent inversions near the origin and terminus. In the flea vector, the bacterium penetrates the gut epithelial barrier and is found in the feces which become infective.

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BLASTP Alignment.txt

Subject: NC_010545:619346 Corynebacterium urealyticum DSM 7109, complete genome

Lineage: Corynebacterium urealyticum; Corynebacterium; Corynebacteriaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: Corynebacterium urealyticum DSM 7109 (ATCC 43042, NCTC 12011) was isolated from a case of cystitis. Corynebacterium urealyticum is a member of normal human skin and mucosal flora. This organism, however, can colonize the urinary tract causing infections.