Query: NC_016940:1698000 Saprospira grandis str. Lewin chromosome, complete genome Lineage: Saprospira grandis; Saprospira; Saprospiraceae; Sphingobacteriales; Bacteroidetes; Bacteria General Information: Gliding bacterium. Saprospira grandis is a gram-negative, marine, multicellular, filamentous flexibacterium. They prey on other bacteria by trapping and devouring them. It is significant because it is known for devouring bacteria and also has been shown to digest algae by the same process. This makes this bacterium important because it is useful in preventing harmful algal blooms. They are mesophilic with their optimum temperature being between 25-30 degrees C, and require a neutral pH. This filamentous organism is matile by gliding. This organism is able to lyse bacterial cells on the surfaces it is moving over.
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General Information: Isolated from a patient with fever and lymphadenitis. Chronic granulomatous disease (CGD) is a rare inherited disease of the phagocyte NADPH oxidase system causing defective production of toxic oxygen metabolites, impaired bacterial and fungal killing, and recurrent life-threatening infections. This species was isolated from a 39 year old man with CGD and was shown to be the causal agent of the disease by classical methods. The isolation of this organism is the first known case of a bacterium from the Acetobacteraceae family to be the cause of an invasive human disease.