Query: NC_016930:165376 Rickettsia philipii str. 364D chromosome, complete genome Lineage: Rickettsia philipii; Rickettsia; Rickettsiaceae; Rickettsiales; Proteobacteria; Bacteria General Information: Rickettsiae are obligate intracellular Gram-negative bacteria mostly found in arthropods, some of which cause mild to severe diseases in humans. Spotted fever group rickettsiae (SFGR) cause disease in humans. R .philippi strain 364D, an SFGR, was isolated in 1966 from Dermacentor occidentalis ticks collected in Ventura county, California, and since then 364D has been detected in up to 11% of D. occidentalis from 8 California counties. It has now been recognized as causing eschar-associated illness.
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General Information: This strain is a spontaneous nalidixic acid-resistant derivative of virulent strain 197. This group of organisms is capable of invading the respiratory tract of animals and causing severe diseases. They express a number of virulence factors in order to do this including filamentous hemagglutins for attachment, cytotoxins, and proteins that form a type III secretion system for transport of effector molecules into host cells. This organism infects the respiratory tract of birds, and causes bordetellosis in commercially important animals such as turkeys, resulting in devastating losses every year due to secondary infections.