Query: NC_016929:1025848 Rickettsia canadensis str. CA410 chromosome, complete genome Lineage: Rickettsia canadensis; Rickettsia; Rickettsiaceae; Rickettsiales; Proteobacteria; Bacteria General Information: Members of this genus, like other Rickettsial organisms such as Neorickettsia and Anaplasma, are obligate intracellular pathogens. In both groups, the bacteria are transmitted via an insect, usually a tick, to a host organism where they target endothelial cells and sometimes macrophages. They attach via an adhesin, rickettsial outer membrane protein A, and are internalized where they persist as cytoplasmically free organisms. This organism was originally thought to be a member of the typhus group of Rickettsiales, however, it is now thought to represent a distict group with the rickettsia.
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General Information: This strain was isolated in 2005 from the urethral fossa of a 4-year-old stallion from a stud farm in the Haute-Savoie, France. This species is a microaerophilic Gram-negative coccobacillus, classified in the Alcaligenaceae family. It is the causative agent of the contagious equine metritis (CEM), a sexually-transmitted infection of horses first reported in 1977, and actually detected in many countries and in various breeds of horses. CEM is characterized in infected mares by abundant mucopurulent vaginal discharge and a variable degree of vaginitis, endometritis and cervicitis that usually result in temporary infertility, whereas no clinical signs have been observed in stallions.