Query: NC_016894:2809125 Acetobacterium woodii DSM 1030 chromosome, complete genome Lineage: Acetobacterium woodii; Acetobacterium; Eubacteriaceae; Clostridiales; Firmicutes; Bacteria General Information: Acetobacterium woodii is a Gram positive, motile, strict anaerobic, acetogenic bacterium, that relies on Na+ as coupling ion in bioenergetic reactions. The organism can use a wide range of substrates, such as sugars, alcohols, methoxylated aromatic acids or C1 compounds. Electrons derived from these electron donors are used in the Wood-Ljungdahl-pathway where the organism fixes CO2 and produces acetate. The pathway of CO2-fixation is coupled to energy conservation via a chemiosmotic mechanism, one enzyme that seems to be involved is the Rnf complex. The produced Na+ gradient can be used to drive ATP-synthesis or flagella rotation. The ATP synthase is a member of the F1FO class of enzymes and has an unusual hybrid rotor. Can use alternative electron acceptors like the lignin degradation product caffeate.
- Sequence; - BLASTP hit: hover for score (Low score = Light, High score = Dark); - hypothetical protein; - cds: hover for description
General Information: This pathogenic strain of Salmonella typhi was isolated in the early 1970s. It contains no multidrug resistance plasmids and has been used for vaccine development. This serovar is a human-specific organism that causes the life-threatening illness Typhoid fever which is acquired by coming into contact with contaminated food or water. Annually, 17 million people are infected, with 600,000 fatalities, mostly in developing countries. It contains multiple fimbrial operons that may be used to create extracellular appendages for attachment and entry into host intestinal epithelial cells. Causes enteric infections. This group of Enterobactericiae have pathogenic characteristics and are one of the most common causes of enteric infections (food poisoning) worldwide. They were named after the scientist Dr. Daniel Salmon who isolated the first organism, Salmonella choleraesuis, from the intestine of a pig. The presence of several pathogenicity islands (PAIs) that encode various virulence factors allows Salmonella spp. to colonize and infect host organisms. There are two important PAIs, Salmonella pathogenicity island 1 and 2 (SPI-1 and SPI-2) that encode two different type III secretion systems for the delivery of effector molecules into the host cell that result in internalization of the bacteria which then leads to systemic spread.