Query: NC_016843:747950 Treponema pallidum subsp. pertenue str. Gauthier chromosome, Lineage: Treponema pallidum; Treponema; Spirochaetaceae; Spirochaetales; Spirochaetes; Bacteria General Information: This strain was isolated in Brazzaville, the Republic of Congo in 1960. Treponema pallidum subsp. pertenue causes chronic and disfiguring illness called yaws. The disease starts as a skin infection causing persistent ulcers and progresses to form tumor-like masses. This disease tends to infect children and is common in rural areas in Africa, Southeast Asia and equatorial South America.
- Sequence; - BLASTP hit: hover for score (Low score = Light, High score = Dark); - hypothetical protein; - cds: hover for description
General Information: This organism is unique in that it is a bacteriolytic microbe that preys on other gram negative bacteria. It is found throughout soil, sewage, and aquatic environments, and is often associated with biofilms. This organism has a biphasic lifestyle which consists of a free living and motile phase, and an attack phase where the bacterium attaches to a host cell, burrows into the periplasm, and begins to degrade the host from the inside out. The organism sheds its flagellum once it makes irreversible contact with the host, and when it is inside, begins to form a bdelloplast, resulting in degradation of the host cell inner membrane and alteration of its peptidoglycan layer, resulting in a spherical cell. The Bdellovibrio cell elongates until it forms a long coiled structure which then divides, forming many flagellated progeny which continue the degradation of the host cell to propagate the life cycle. The genome encodes a large number of degradative and lytic enzymes which are used to degrade the host organism. The organism has numerous deficiencies in its amino acid biosynthetic pathways, suggesting it utilizes prey metabolites for protein synthesis.