Query: NC_016786:1359064 Corynebacterium diphtheriae HC01 chromosome, complete genome Lineage: Corynebacterium diphtheriae; Corynebacterium; Corynebacteriaceae; Actinomycetales; Actinobacteria; Bacteria General Information: They may be found as members of the normal microflora of humans, where these bacteria find a suitable niche in virtually every anatomic site. This organism is the best known and most widely studied species of the genus. It is the causal agent of the disease diphtheria, a deadly infectious disease spreading from person to person by respiratory droplets from the throat through coughing and sneezing. In the course of infection, the bacteria invade and colonize tissues of the upper respiratory tract, proliferate and produce exotoxin that inhibits protein synthesis and causes local lesions and systemic degenerative changes in the heart, muscles, peripheral nerves, liver and other vital organs.
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General Information: This bacterium is named after Simona Kahane who discovered the organism as a contaminant in cell cultures at Ber Sheva, in the Negev Desert, Israel, in 1993. Simkania negevensis is a member of the order Chlamydiales and can reside intracellularly and has a slow prolonged developmental cycle. It has a wide geographical and environmental distribution and is associated with pneumonia, bronchiolitis and chronic obstructive pulmonary disease, furthermore, it is completely resistant to penicillin and to bacitracin. The natural hosts of Simkania negevensis bacteria might be amoebae.