Query: NC_016779:5009320 Bacillus cereus F837/76 chromosome, complete genome Lineage: Bacillus cereus; Bacillus; Bacillaceae; Bacillales; Firmicutes; Bacteria General Information: This organism is a soil-dwelling opportunistic pathogen that causes food poisoning in infected individuals. The rapid onset is characterized by nausea and vomiting while the late onset is characterized by diarrhea and abdominal pain. The emetic disease is caused by a small stable dodecadepsipeptide cerulide whereas the diarrheal disease is caused by a heat labile enterotoxin. Some strains produce a potent cytotoxin that forms a pore in the membrane of eukaryotic cells and causes necrotic enteritis (death of intestinal epithelial cells) while the unique tripartite membrane lytic toxin hemolysin BL contributes to the diarrheal disease and destructive infections of the eye.
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General Information: This organism was isolated from the Dead Sea and will provide information on the proteins necessary for adaptation to a high salt environment. Halophilic archaeon. Halobacterial species are obligately halophilic microorganisms that have adapted to optimal growth under conditions of extremely high salinity 10 times that of sea water. They contain a correspondingly high concentration of salts internally and exhibit a variety of unusual and unique molecular characteristics. Since their discovery, extreme halophiles have been studied extensively by chemists, biochemists, microbiologists, and molecular biologists to define both molecular diversity and universal features of life. A notable list of early research milestones on halophiles includes the discovery of a cell envelope composed of an S-layer glycoprotein, archaeol ether lipids and purple membrane, and metabolic and biosynthetic processes operating at saturating salinities. These early discoveries established the value of investigations directed at extremophiles and set the stage for pioneering phylogenetic studies leading to the three-domain view of life and classification of Halobacterium as a member of the archaeal domain. This organism is also know as "Halobacterium of the Dead Sea". Growth occurs in 1.7-5.1 M NaCl with optimum salt concentration of 3.4-3.9 M NaCl. The cytosol of this organism is a supersaturated salt solution in which proteins are soluble and active. This halophile is chemoorganotrophic and able to use a wide variety of compounds as sole carbon and energy sources.