Query: NC_016638:429437 Mycoplasma haemocanis str. Illinois chromosome, complete genome Lineage: Mycoplasma haemocanis; Mycoplasma; Mycoplasmataceae; Mycoplasmatales; Tenericutes; Bacteria General Information: Mycoplasma haemocanis has been widely studied due to its role as a veterinary pathogen that usually causes latent infection in the dog until splenectomy or immunosuppression trigger overt disease. The strain Illinois of M. haemocanis is pathogenic to the host; it was harvested from the blood of a naturally infected 8-year-old splenectomized dog and used for this genomic sequencing project.
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General Information: Causative agent of plague. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.