Query: NC_016630:1385719 Filifactor alocis ATCC 35896 chromosome, complete genome Lineage: Filifactor alocis; Filifactor; Peptostreptococcaceae; Clostridiales; Firmicutes; Bacteria General Information: Filifactor alocis, originally known as Fusobacterium alocis, was first isolated in1985 from the human gingival crevice, and has since been discovered in patients suffering from chronic periodontitis, generalized aggressive, periodontitis and endodontic infections. It has also been isolated from feline soft tissue infections. It is a fastidious, Gram-positive obligately anaerobic rod. Bacteria in periodontal pockets develop complex sessile communities that attach to the tooth surface.
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General Information: This strain is a well studied producer of endoglucanase and several restriction endonucleases. Thermophilic cellulose degrading bacterium. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. Some species are capable of producing organic solvents (acetone, ethanol, etc,), molecular hydrogen and other useful compounds. This organism is a thermophilic anaerobe that produces an extracellular enzyme system capable of degrading crystalline cellulose to soluble sugars that are further utilized as the carbon source for growth.