Query: NC_016612:3803130 Klebsiella oxytoca KCTC 1686 chromosome, complete genome
Lineage: Klebsiella oxytoca; Klebsiella; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria
General Information: This bacterium can cause spontaneous infectious spondylodiscitis (SIS), an uncommon cause of low back pain in adults, but most commonly described in children. This species can be differentiated from Klebsiella pneumoniae by its inability to produce indole from tryptophan.
Subject: NC_008767:273759 Neisseria meningitidis FAM18, complete genome
Lineage: Neisseria meningitidis; Neisseria; Neisseriaceae; Neisseriales; Proteobacteria; Bacteria
General Information: Isolated from a patient with meningococcal septicemia. Causes septicemia and meningitis. The second of two pathogenic Neisseria, this organism causes septicemia and is the leading cause of life-threatening meningitis (inflammation of the meninges, the membrane surrounding the brain and spinal cord) in children. This organism typically residies in the nasopharynx cavity but can invade the respiratory epthelial barrier, cross into the bloodstream and the blood brain barrier, and cause inflammation of the meninges. Pathogenicity factors include the surface proteins (porins and opacity proteins), and the type IV pilus (which is also found in Neisseria gonorrhoeae). Pathogenicity factors include the surface proteins (porins and opacity proteins), and the type IV pilus (which is also found in Neisseria gonorrhoeae). This organism, like Neisseria gonorrhoeae, is naturally competent, and protein complexes at the cell surface recognize the uptake signal sequence in extracellular DNA, an 8mer that is found at high frequency in Neisseria chromosomal DNA.