Query: NC_016610:3297080 Tannerella forsythia ATCC 43037 chromosome, complete genome Lineage: Tannerella forsythia; Tannerella; Porphyromonadaceae; Bacteroidales; Bacteroidetes; Bacteria General Information: This organism is a key agent in the progression of periodontal disease and is involved in bone loss and loss of attachment of teeth. The pathogenic factors involved in this are poorly understood. Unlike other periodontal organism such as Porphyromonas gingivalis and Prevotella intermedia, this organism is difficult to culture and the prevalence of the organism in periodontal disease may be underestimated. This organism is synergistic with Porphyromonas gingivalis, and the presence of both accelerates progression of the disease.
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General Information: Industrially important bacterium. Under starvation conditions this group of bacteria initiate a pathway that leads to endospore formation, a process that is thoroughly studied and is a model system for prokaryotic development and differentiation. Spores are highly resistant to heat, cold, dessication, radiation, and disinfectants, and enable the organism to persist in otherwise inhospitable environments. Under more inviting conditions the spores germinate to produce vegetative cells. This organism is a soil-dwelling endospore-forming microbe similar to other Bacilli. This bacterium is used extensively in the industrial production of important enzymes such as proteases, penicllinases, and amylases as well as smaller compounds like the antibiotic bacitracin and various organic metabolites. This organism is closely related to Bacillus subtilis on the basis of rRNA typing, and it has been found to occasionally cause illness in humans.