Query: NC_016610:3297080 Tannerella forsythia ATCC 43037 chromosome, complete genome Lineage: Tannerella forsythia; Tannerella; Porphyromonadaceae; Bacteroidales; Bacteroidetes; Bacteria General Information: This organism is a key agent in the progression of periodontal disease and is involved in bone loss and loss of attachment of teeth. The pathogenic factors involved in this are poorly understood. Unlike other periodontal organism such as Porphyromonas gingivalis and Prevotella intermedia, this organism is difficult to culture and the prevalence of the organism in periodontal disease may be underestimated. This organism is synergistic with Porphyromonas gingivalis, and the presence of both accelerates progression of the disease.
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General Information: Clostridium difficile R20291 was isolated in Stoke Mandeville Hospital, UK in 2006 and is closely related to the North American hypervirulent BI strains. Clostridium difficile, a Gram-positive, spore-forming anaerobic bacterium, is the leading cause of infectious diarrhea among patients in hospitals worldwide, causing C. difficile infection (CDI). An important nosocomial pathogen, it is frequently associated with antibiotic treatment and causes diseases ranging from antibiotic-associated diarrhea to life-threatening pseudomembraneous colitis.