Query: NC_016516:1345840 Propionibacterium acnes TypeIA2 P.acn33 chromosome, complete Lineage: Propionibacterium acnes; Propionibacterium; Propionibacteriaceae; Actinomycetales; Actinobacteria; Bacteria General Information: This bacterium is the most common gram-positive, non-spore forming, anaerobic rod encountered in clinical specimens. The causative agent of acne, it typically grows as an obligate anaerobe. Some strains are aerotolerant, but still show better growth as an anaerobe. It has the ability to produce propionic acid, as its name suggests. It also has the ability to produce catalase along with indole, nitrate, or both indole and nitrate. Propionibacterium resembles Corynebacterium in morphology and arrangement, but is non-toxigenic. It is a common resident of the pilosebaceous (hair follicle) glands of the human skin. The bacteria release lipases to digest a surplus of the skin oil, sebum, that has been produced. The combination of digestive products (fatty acids) and bacterial antigens stimulates an intense local inflammation that bursts the hair follicle. Since acne is caused in part from an infection, it can be suppressed with topical and oral antibiotics such as clindamycin, erythromycin, or tetracycline. Some other forms of therapy include chemicals that enhance skin removal or slow the production of sebum.
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General Information: Gram-negative soil bacterium. This is the most widely studied species in the genus. Strains of Agrobacterium are classified in three biovars based on their utilisation of different carbohydrates and other biochemical tests. The differences between biovars are determined by genes on the single circle of chromosomal DNA. Biovar differences are not particularly relevant to the pathogenicity of A. tumefaciens, except in one respect: biovar 3 is found worldwide as the pathogen of gravevines. This species causes crown gall disease of a wide range of dicotyledonous (broad-leaved) plants, especially members of the rose family such as apple, pear, peach, cherry, almond, raspberry and roses. Because of the way that it infects other organisms, this bacterium has been used as a tool in plant breeding. Any desired genes, such as insecticidal toxin genes or herbicide-resistance genes, can be engineered into the bacterial DNA, and then inserted into the plant genome. This process shortens the conventional plant breeding process, and allows entirely new (non-plant) genes to be engineered into crops.