Pre_GI: SWBIT SVG BLASTP

Query: NC_016512:2506898 Propionibacterium acnes TypeIA2 P.acn17 chromosome, complete

Lineage: Propionibacterium acnes; Propionibacterium; Propionibacteriaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: This bacterium is the most common gram-positive, non-spore forming, anaerobic rod encountered in clinical specimens. The causative agent of acne, it typically grows as an obligate anaerobe. Some strains are aerotolerant, but still show better growth as an anaerobe. It has the ability to produce propionic acid, as its name suggests. It also has the ability to produce catalase along with indole, nitrate, or both indole and nitrate. Propionibacterium resembles Corynebacterium in morphology and arrangement, but is non-toxigenic. It is a common resident of the pilosebaceous (hair follicle) glands of the human skin. The bacteria release lipases to digest a surplus of the skin oil, sebum, that has been produced. The combination of digestive products (fatty acids) and bacterial antigens stimulates an intense local inflammation that bursts the hair follicle. Since acne is caused in part from an infection, it can be suppressed with topical and oral antibiotics such as clindamycin, erythromycin, or tetracycline. Some other forms of therapy include chemicals that enhance skin removal or slow the production of sebum.

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BLASTP Alignment.txt

Subject: NC_008578:2431074 Acidothermus cellulolyticus 11B, complete genome

Lineage: Acidothermus cellulolyticus; Acidothermus; Acidothermaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: This organism is a thermotolerant cellulolytic actinomycete that was originally isolated from an acidic hot spring in Yellowstone National Park. A number of thermostable endoglucanases are produced by this organism, which are useful for degrading cellulose in the production of ethanol as a biofuel.