Pre_GI: SWBIT SVG BLASTP

Query: NC_016114:1474000 Streptomyces flavogriseus ATCC 33331 chromosome, complete genome

Lineage: Streptomyces pratensis; Streptomyces; Streptomycetaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: Environment: Soil; Isolation: Soil; Temp: Mesophile. The genus Streptomyces consists of soil and water Gram positive filamentous bacteria well known for their ability to produce complex secondary metabolites including many antibiotics. Additionally they undergo complex multicellular development, with spores germinating to form a branched, multinucleoid substrate mycelium, which then produces an aerial mycelium which septates into uninucleoid spores. Streptomyces flavogriseus is an aerobic, Gram-positive bacterium isolated from soil. This organism produces cellulases and xyanases that are able to degrade cellulose and xylan.

Subject: NC_009142:2725000 Saccharopolyspora erythraea NRRL 2338, complete genome

Lineage: Saccharopolyspora erythraea; Saccharopolyspora; Pseudonocardiaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: Source of the antibiotic erythromycin. Saccharopolyspora erythraea is the soil bacterium that produces the industrially important antibiotic erythromycin A. Erythromycin is a clinically important and potent macrolide antibiotic. It is used to treat infections caused by several prokaryotic pathogens such as Streptococcus, Staphylococcus, Mycoplasma, Ureaplasma, Chlamydia and Legionella. Production of this antibiotic is lower than others in the same class, such as penicillin or cephalosporin, which has led to the development of a genetic system to attempt to enhance the production of erythromycin.