Pre_GI: SWBIT SVG BLASTP

Query: NC_015848:1105892 Mycobacterium canettii CIPT 140010059, complete genome

Lineage: Mycobacterium canettii; Mycobacterium; Mycobacteriaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: The Republic of Djibouti, Africa appears to be an exceptional place in terms of tuberculosis (TB) caused by Mycobacterium canettii, a highly unusual tubercle bacillus with unusual smooth colony morphology (STB) related to the M. tuberculosis complex (MTBC). M. canettii was first isolated from a 20-year-old French farmer suffering from pulmonary tuberculosis by G. Canetti in 1969. Since then, this strain has been isolated on rare occasions from patients who lived or were presumably infected in East Africa. It tends to preferentially affect children and foreigners in the Horn of Africa. M. canettii, a possible ancestor of the MTBC, is found almost exclusively in the Horn of Africa where TB is thought to have emerged about 40 000 years ago, coinciding with the expansion of human population out of Africa. The geographical restriction of M. canettii isolates and contrasting genetic diversity are characteristics compatible with a non-human reservoir. With the larger pan-genome reflecting the ancestral, wider gene pool of tubercle bacilli, their lower virulence and faster growth, especially at temperatures below 37 degrees C, plausibly reflecting broader environmental adaptability, STB strains might thus come nearer to the as-yet-unknown missing link between the obligate pathogen M. tuberculosis and environmental mycobacteria (adapted from PMIDs 20831613 and 23291586). Mycobacteria have an unusual outer membrane approximately 8nm thick, despite being considered Gram-positive. The outer membrane and the mycolic acid-arabinoglactan-peptidoglycan polymer form the cell wall, which constitutes an efficient permeability barrier in conjunction with the cell inner membrane.

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BLASTP Alignment.txt

Subject: NC_012803:1094679 Micrococcus luteus NCTC 2665, complete genome

Lineage: Micrococcus luteus; Micrococcus; Micrococcaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: Temp: Mesophile; Habitat: Soil. Micrococcus luteus NCTC 2665 has potential in bioremediation due to its ability to sequester metals (i.e. gold and strontium), and it is being used for gold concentration from low-abundance ores. Micrococcus luteus was originally isolated by Alexander Fleming in 1929 as Micrococcus lysodeikticus. This organism can be found in many environments including soil, water, animals, and dairy products. Micrococcus luteus is able to survive in the environment for long periods and has been isolated from inclusions in amber.