Query: NC_015672:2102580 Flexistipes sinusarabici DSM 4947 chromosome, complete genome Lineage: Flexistipes sinusarabici; Flexistipes; Deferribacteraceae; Deferribacterales; Deferribacteres; Bacteria General Information: Country: Red Sea; Environment: Marine; Isolation: Brine water; Atlantis II Deep, Red Sea; Temp: Thermophile; Temp: 45 - 50C. This is a gram-negative flexible bacterium isolated from brine water samples of the Atlantis II Deep of the Red Sea at a depth of 2000 m. Halophilic and moderately thermophilic.
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General Information: Isolated from a patient with fever and lymphadenitis. Chronic granulomatous disease (CGD) is a rare inherited disease of the phagocyte NADPH oxidase system causing defective production of toxic oxygen metabolites, impaired bacterial and fungal killing, and recurrent life-threatening infections. This species was isolated from a 39 year old man with CGD and was shown to be the causal agent of the disease by classical methods. The isolation of this organism is the first known case of a bacterium from the Acetobacteraceae family to be the cause of an invasive human disease.