Query: NC_015573:3070582 Desulfotomaculum kuznetsovii DSM 6115 chromosome, complete genome Lineage: Desulfotomaculum kuznetsovii; Desulfotomaculum; Peptococcaceae; Clostridiales; Firmicutes; Bacteria General Information: Country: Georgia; Environment: Animal intestinal microflora, Fresh water; Isolation: underground thermal mineral water; Temp: Mesophile; Temp: 60C. Desulfotomaculum kuznetsovii is a thermophilic spore-forming bacterium which can grow using sulfate as an electron acceptor. This organism is isolate from hot springs and oil field samples.
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General Information: This genus, like other Rickettsial organisms such as Neorickettsia and Anaplasma, is composed of obligate intracellular pathogens. The latter is composed of two organisms, Rickettsia prowazekii and Rickettsia typhi. The bacteria are transmitted via an insect, usually a tick, to a host organism, in this case humans, where they target endothelial cells and sometimes macrophages. They attach via an adhesin, rickettsial outer membrane protein A, and are internalized where they persist as cytoplasmically free organisms. Transovarial transmission (from mother to offspring) occurs in the invertebrate host. Rickettsia typhi causes murine typhus and is an obligate intracellular pathogen that infects both the flea vector and hosts such as human, rat, and mouse. In the flea vector, the bacterium penetrates the gut epithelial barrier and is found in the feces which become infective.