Query: NC_014932:985882 Bartonella clarridgeiae 73, complete genome Lineage: Bartonella clarridgeiae; Bartonella; Bartonellaceae; Rhizobiales; Proteobacteria; Bacteria General Information: Bartonella clarridgeiae was first identified from a case of cat scratch fever in a veterinarian who had been bitten by a cat. This organism has subsequently been identified in both cats and dogs. Cats, which are infected by fleas carrying the bacteria, in turn infect humans when scratching or biting them, hence the name. A small red bump forms at the site of infection, followed 2-3 weeks later by a painful swelling of the lymph node. In immunocompromized patients, more severe progress may be observed, including encephalitis, swelling of the spleen, and heart valve infection. Approximately 24 000 cases are reported in the US each year.
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General Information: This subspecies is virulent in humans, and the strain is a clinical isolate that is also virulent in an animal model. Originally isolated from a human case of tularemia in 1951. There are a large number of insertion sequences including a mariner element, which is a transposon typically found in eukaryotes and is the first instance of this element to be found in a microbe, which may have acquired it during transit through one of the insect vectors. Causative agent of tularemia. This organism was first identified by Edward Francis as the causative agent of a plague-like illness that affected squirrels in Tulare county in California in the early part of the 20th century. The organism now bears his name. The disease, which has been noted throughout recorded history, can be transmitted to humans by infected ticks or deerflies, infected meat, or by aerosol, and thus is a potential bioterrorism agent. This organism has a high infectivity rate, and can invade phagocytic and nonphagocytic cells, multiplying rapidly. Once within a macrophage, the organism can escape the phagosome and live in the cytosol. It is an aquatic organism, and can be found living inside protozoans, similar to what is observed with Legionella.