Query: NC_014921:313312 Mycoplasma fermentans M64 chromosome, complete genome
Lineage: Mycoplasma fermentans; Mycoplasma; Mycoplasmataceae; Mycoplasmatales; Tenericutes; Bacteria
General Information: Mycoplasma fermentans has been isolated from the respiratory and urogenital tract, primarily from immunocompromised patients and may be a factor in the progression of HIV infection to AIDS. In addition this organism can be detected in the blood and joints of patients with rheumatoid arthritis.
Subject: NC_010263:167450 Rickettsia rickettsii str. Iowa, complete genome
Lineage: Rickettsia rickettsii; Rickettsia; Rickettsiaceae; Rickettsiales; Proteobacteria; Bacteria
General Information: Causative agent for Rocky Mountain Spotted Fever. This organism was first identified by Dr. Howard Rickets as the causative agent of Rocky Mountain Spotted Fever, which was originally named for its geographic distribution at the time, it is now known to be widespread throughout the North American continent. This bacterium is an obligate intracellular pathogen that infects primarily the vascular endothelium, and occasionally smooth muscle tissue. It is passed to the human host from a tick bite, and the tick acts as both a natural reservoir and a vector for disease transmission. Once the organism is endocytosed by the host cell, it quickly escapes the phagozome, and replicates intracellularly, causing cell death and tissue damage. The disease is characterized by a spotted rash and has a high mortality rate if left untreated.