Query: NC_014830:335380 Intrasporangium calvum DSM 43043 chromosome, complete genome Lineage: Intrasporangium calvum; Intrasporangium; Intrasporangiaceae; Actinomycetales; Actinobacteria; Bacteria General Information: Country: Russia; Environment: Air; Isolation: Air in a school dining room; Temp: Mesophile; Temp: 37C; The organism was isolated on a meat-extract peptone agar plate from the air in aschool dining room. This organism produces branching mycelium and produces sporangia intercalary in the mycelial hyphae.
- Sequence; - BLASTP hit: hover for score (Low score = Light, High score = Dark); - hypothetical protein; - cds: hover for description
General Information: This genus, like other Rickettsial organisms such as Neorickettsia and Anaplasma, is composed of obligate intracellular pathogens. The latter is composed of two organisms, Rickettsia prowazekii and Rickettsia typhi. The bacteria are transmitted via an insect, usually a tick, to a host organism, in this case humans, where they target endothelial cells and sometimes macrophages. They attach via an adhesin, rickettsial outer membrane protein A, and are internalized where they persist as cytoplasmically free organisms. Transovarial transmission (from mother to offspring) occurs in the invertebrate host. Rickettsia typhi causes murine typhus and is an obligate intracellular pathogen that infects both the flea vector and hosts such as human, rat, and mouse. In the flea vector, the bacterium penetrates the gut epithelial barrier and is found in the feces which become infective.