Query: NC_014666:4043279 Frankia sp. EuI1c chromosome, complete genome Lineage: Frankia; Frankia; Frankiaceae; Actinomycetales; Actinobacteria; Bacteria General Information: Environment: Host, Plant symbiont, Soil; Temp: Mesophile. Frankia sp. EuI1c was isolated from the Autumn olive, Elaeagnus umbellata. Frankia sp. (strain EuI1c) is an aerobic Gram-positive bacterium isolated from four continents (North America, South America, Africa, and Asia) and different habitats, including dry soils with high salinity levels, steppe-like plains at 900 m, and mountain forests at 3,000 m.
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General Information: Isolated from a patient with fever and lymphadenitis. Chronic granulomatous disease (CGD) is a rare inherited disease of the phagocyte NADPH oxidase system causing defective production of toxic oxygen metabolites, impaired bacterial and fungal killing, and recurrent life-threatening infections. This species was isolated from a 39 year old man with CGD and was shown to be the causal agent of the disease by classical methods. The isolation of this organism is the first known case of a bacterium from the Acetobacteraceae family to be the cause of an invasive human disease.